Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20370299 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL2549893 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL5676529 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL145250 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL30962277 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL1440790 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL1071722 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL13993046 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL113492 | 1.00 | THRB (0.47) | THRBMEN1KMT2A | |
| SCHEMBL15572000 | 0.97 | THRB (0.45) | THRBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 731 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12122788-B2 | Process of making CFTR modulators | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2024-10-22 | — | — | US | claimed |
| CN-115894884-B | Trifunctional organic catalyst and preparation method and application thereof | 浙江大学 | 2024-07-05 | — | — | CN | claimed |
| US-20240166595-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS | GENENTECH, INC. (US) | 2024-05-23 | — | — | US | claimed |
| EP-4347574-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS | Genentech, Inc. (US) | 2024-04-10 | — | — | EP | claimed |
| US-20230399343-A1 | PROCESS OF MAKING CFTR MODULATORS | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC | 2023-12-14 | — | — | US | claimed |
| US-20230234956-A1 | METHODS OF MAKING WEE1 INHIBITOR COMPOUNDS | RECURIUM IP HOLDINGS, LLC | 2023-07-27 | — | — | US | claimed |
| EP-3851441-B1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE | HOFFMANN LA ROCHE (CH) | 2023-06-28 | — | — | EP | claimed |
| CN-115894884-A | Trifunctional organic catalyst, and preparation method and application thereof | 浙江大学 | 2023-04-04 | — | — | CN | claimed |
| WO-2022251567-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS | GENENTECH, INC. (US) | 2022-12-01 | — | — | WO | claimed |
| EP-3851441-A1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE | F. Hoffmann-La Roche AG (CH) | 2021-07-21 | — | — | EP | claimed |
| EP-3555107-B1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO)PROPANAMIDE | HOFFMANN LA ROCHE (CH) | 2021-02-17 | — | — | EP | claimed |
| US-10781219-B2 | Process for the preparation of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[F]imidazo[1,2-D][1,4]oxazepin-9-yl)amino) propanamide | GENENTECH, INC. (US) | 2020-09-22 | — | — | US | claimed |
| EP-3555107-A1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE | H. Hoffnabb-La Roche Ag (CH) | 2019-10-23 | — | — | EP | claimed |
| US-20190292201-A1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROP AN AMIDE | GENENTECH, INC. (US) | 2019-09-26 | — | — | US | claimed |
| CN-109046449-A | A kind of tertiary amine-Thiourea bifunctional chiral catalyst and the preparation method and application thereof | 石家庄学院 | 2018-12-21 | — | — | CN | claimed |
| WO-2018109204-A1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROPANAMIDE | F. HOFFMANN-LA ROCHE AG (CH) | 2018-06-21 | — | — | WO | claimed |
| EP-1442050-B1 | LINEAR BASIC COMPOUNDS HAVING NK-2 ANTAGONIST ACTIVITY AND FORMULATIONS THEREOF | MALESCI SAS (IT) | 2006-09-13 | — | — | EP | claimed |
| WO-2026103930-A1 | IMIDAZOL-2-ONE DERIVATIVE AND PHARMACEUTICAL USE THEREOF | 西藏海思科制药有限公司 | 2026-05-21 | — | — | WO | disclosed |
| US-4145435-A | 2-AMINOCYCLOALIPHATIC AMIDE COMPOUNDS | THE UPJOHN COMPANY (US) | 1979-03-20 | — | — | US | disclosed |
| US-4098904-A | ANALGESIC N-(2-AMINOCYCLOALIPHATIC)BENZAMIDES | THE UPJOHN COMPANY (US) | 1978-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230399343-A1 | PROCESS OF MAKING CFTR MODULATORS | CFTR, SLC26A4, TMEM109 | THRB 2612/4885MEN1 2440/4885KMT2A 4522/4885 |
| US-10781219-B2 | Process for the preparation of (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[F]imidazo[1,2-D][1,4]oxazepin-9-yl)amino) propanamide | CACNA1D, CACNA1B, KCNMB4 | THRB 3576/4885MEN1 4033/4885KMT2A 1843/4885 |
| US-20190292201-A1 | PROCESS FOR THE PREPARATION OF (S)-2-((2-((S)-4-(DIFLUOROMETHYL)-2-OXOOXAZOLIDIN-3-YL)-5,6-DIHYDROBENZO[F]IMIDAZO[1,2-D][1,4]OXAZEPIN-9-YL)AMINO) PROP AN AMIDE | CACNG4, KCNJ4, CYP2J2 | THRB 3413/4885MEN1 4156/4885KMT2A 1866/4885 |
| US-20230234956-A1 | METHODS OF MAKING WEE1 INHIBITOR COMPOUNDS | WEE1, WEE2, CCNE1 | THRB 4259/4885MEN1 535/4885KMT2A 1139/4885 |
| US-20240166595-A1 | PROCESS FOR THE PREPARATION OF BENZOXAZEPIN OXAZOLIDINONE COMPOUNDS | CYP2C18, CYP2C19, CYP4X1 | THRB 3901/4885MEN1 3393/4885KMT2A 2322/4885 |
| US-12122788-B2 | Process of making CFTR modulators | CFTR, SLC26A4, TMEM109 | THRB 2612/4885MEN1 2440/4885KMT2A 4522/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.