Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 7/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GPR6 | P46095 | 1/20 | 0.32 |
| ▸ | CASP6 | P55212 | 1/20 | 0.32 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL1874802 | 0.91 | PPARG (0.32) | BTKSCN9APPARGPPARA | |
| Trifluoroacetic Acid SCHEMBL1878705 | 0.88 | CCR2 (0.37) | BTK | |
| Trifluoroacetic Acid SCHEMBL1875571 | 0.86 | PPARA (0.38) | BTKPPARGPPARA | |
| Trifluoroacetic Acid SCHEMBL1878083 | 0.85 | OPRM1 (0.37) | LMNAROCK2ROCK1CASP6 | |
| SCHEMBL12634097 | 0.84 | LMNA (0.40) | BTKLMNACASP6 | |
| Trifluoroacetic Acid SCHEMBL1876380 | 0.82 | QPCT (0.34) | PPARGPPARA | |
| Trifluoroacetic Acid SCHEMBL1877301 | 0.82 | GHSR (0.37) | P2RX7GPR6 | |
| Trifluoroacetic Acid SCHEMBL1879078 | 0.80 | SCN9A (0.41) | SCN9A | |
| SCHEMBL13137140 | 0.80 | BMPR1B (0.37) | LMNAMAPTCASP6 | |
| Trifluoroacetic Acid SCHEMBL1876615 | 0.79 | PTPN2 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7939528-B2 | Heterocycle compounds | GLAXOSMITHKLINE LLC (US) | 2011-05-10 | — | — | US | disclosed |