Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | HBB | P68871 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13543165 | 0.87 | CTBP2 (0.51) | HSD11B1ALDH1A1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL10419287 | 0.87 | AKR1B1 (0.61) | HSD11B1AKR1B1GABRA1GABRB2ALDH1A1 | |
| SCHEMBL8906082 | 0.87 | SLC6A4 (0.40) | HSD11B1ALDH1A1HTTKMT2ASMN1; SMN2 | |
| SCHEMBL8446184 | 0.86 | ALDH1A1 (0.50) | ALDH1A1KMT2ARAB9AMAPK1 | |
| SCHEMBL13012097 | 0.86 | RIPK1 (0.49) | HSD11B1ALDH1A1KMT2ARAB9A | |
| SCHEMBL19224348 | 0.86 | ALDH1A1 (0.42) | HSD11B1AKR1B1ALDH1A1HTTNR1H4 | |
| SCHEMBL8677292 | 0.86 | RIPK1 (0.49) | HSD11B1ALDH1A1RAB9AMAPK1 | |
| SCHEMBL20355736 | 0.84 | BCAT2 (0.41) | HSD11B1AKR1B1ALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL12680316 | 0.84 | ALDH1A1 (0.42) | HSD11B1AKR1B1GABRA1GABRB2ALDH1A1 | |
| SCHEMBL5673265 | 0.83 | DUSP3 (0.47) | HSD11B1AKR1B1GABRA1GABRB2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10017556-B2 | Insulin receptor partial agonists | MERCK SHARP & DOHME CORP. (US) | 2018-07-10 | — | — | US | disclosed |
| US-20170355743-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-12-14 | — | — | US | disclosed |
| US-20170107268-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | MERCK SHARP & DOHME CORP. (US) | 2017-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355743-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | INSR, GPR119, IRS1 | HSD11B1 2587/4885AKR1B1 1623/4885GABRA1 184/4885 |
| US-10017556-B2 | Insulin receptor partial agonists | INSR, GPR119, IRS1 | HSD11B1 2587/4885AKR1B1 1623/4885GABRA1 184/4885 |
| US-20170107268-A1 | INSULIN RECEPTOR PARTIAL AGONISTS | INSR, GPR119, IRS1 | HSD11B1 2587/4885AKR1B1 1623/4885GABRA1 184/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.