Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | GCK | P35557 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7468141 | 0.83 | APP (0.49) | KDM4EALKLMNAMEN1ALDH1A1 | |
| SCHEMBL12004357 | 0.82 | MET (0.48) | KDM4EALKMETPDGFRAKDR | |
| SCHEMBL19633787 | 0.81 | FGFR2 (0.48) | KDM4EALKPDGFRAKDRALDH1A1 | |
| SCHEMBL12004095 | 0.77 | HSPB1 (0.46) | ALKMETPDGFRAKDRMEN1 | |
| SCHEMBL13739661 | 0.77 | SRC (0.60) | METSRCTGFBR1PDGFRAKDR | |
| SCHEMBL2178592 | 0.76 | KDR (0.43) | ALKMETPDGFRAKDR | |
| SCHEMBL7461560 | 0.71 | LMNA (0.51) | LMNAMEN1ALDH1A1KMT2A | |
| SCHEMBL18265407 | 0.71 | KDR (0.56) | ALKMETSRCTGFBR1PDGFRA | |
| SCHEMBL5223147 | 0.71 | MET (0.58) | METSRCTGFBR1KDR | |
| Ammonia Solution, Strong SCHEMBL2063874 | 0.71 | MET (0.57) | METSRCTGFBR1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532657-B9 | Compounds and methods of use | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-04-19 | — | — | EP | disclosed |