Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | THRB | P10828 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | DRD2 | P14416 | 4/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 3/20 | 0.54 |
| ▸ | DRD3 | P35462 | 5/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.51 |
| ▸ | ALPL | P05186 | 2/20 | 0.50 |
| ▸ | ALPI | P09923 | 2/20 | 0.50 |
| ▸ | ALPG | P10696 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768440 | 0.85 | TP53 (0.70) | TP53LMNATHRBDRD2CXCR4 | |
| SCHEMBL18768421 | 0.85 | KMT2A (0.58) | ACHETP53LMNATHRBSLC6A2 | |
| SCHEMBL18768559 | 0.85 | GSK3B (0.60) | ACHEBACE1TP53LMNADRD4 | |
| SCHEMBL18768629 | 0.83 | GSK3B (0.59) | ACHEBACE1TP53LMNADRD4 | |
| SCHEMBL18768573 | 0.83 | SLC6A2 (0.66) | ACHEBACE1TP53LMNADRD4 | |
| SCHEMBL18768364 | 0.82 | LMNA (0.69) | ACHEBACE1TP53LMNADRD4 | |
| SCHEMBL18768626 | 0.81 | MEN1 (0.46) | ACHECXCR4 | |
| SCHEMBL18767964 | 0.81 | SLC6A2 (0.59) | DRD2DRD3SLC6A2SLC6A4 | |
| SCHEMBL18768420 | 0.81 | LMNA (0.57) | ACHEBACE1TP53LMNADRD4 | |
| SCHEMBL6661461 | 0.80 | ROCK2 (0.59) | DRD4DRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |