Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.35 |
| ▸ | FNTB | P49356 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18772024 | 0.92 | TLR8 (0.56) | TLR8TLR7FNTAFNTBPGR | |
| SCHEMBL18771963 | 0.87 | MMP2 (0.41) | TLR8TLR7ALDH1A1HPGD | |
| SCHEMBL18771798 | 0.86 | TLR8 (0.39) | TLR8TLR7 | |
| SCHEMBL18771933 | 0.85 | TLR8 (0.34) | TLR8TLR7MAPTKDM4EALDH1A1 | |
| SCHEMBL18772002 | 0.85 | HPGD (0.37) | TLR8TLR7HRH3MAPTTSHR | |
| SCHEMBL18771974 | 0.82 | MMP2 (0.45) | TLR8TLR7L3MBTL1MAPTTSHR | |
| SCHEMBL19265523 | 0.82 | TLR8 (0.35) | TLR8TLR7MAPTTSHRSMN1; SMN2 | |
| SCHEMBL18771727 | 0.82 | TLR8 (0.42) | TLR8TLR7L3MBTL1HRH3TSHR | |
| SCHEMBL18772124 | 0.81 | TLR8 (0.38) | TLR8TLR7TSHRLMNAHPGD | |
| SCHEMBL19265526 | 0.81 | TLR8 (0.40) | TLR8TLR7MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3159337-A2 | SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | Ventirx Pharmaceuticals, Inc. (US) | 2017-04-26 | — | — | EP | disclosed |