Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.40 |
| ▸ | OGFRL1 | Q5TC84 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | GRK6 | P43250 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17582784 | 0.82 | RPS6KB1 (0.48) | OPRM1OPRK1OGFRL1L3MBTL1NPC1 | |
| SCHEMBL21310911 | 0.79 | ALDH1A1 (0.52) | OPRM1OPRK1OGFRL1L3MBTL1OPRD1 | |
| SCHEMBL17582904 | 0.77 | NPSR1 (0.39) | OPRM1OPRK1OGFRL1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2337873 | 0.75 | SMN1; SMN2 (0.50) | OPRM1OPRK1SMN1; SMN2L3MBTL1NPSR1 | |
| SCHEMBL21310910 | 0.74 | GRK6 (0.46) | NPC1RAB9ARPS6KB1GRK6KDM4E | |
| SCHEMBL15199159 | 0.74 | ALK (0.51) | METALKOPRM1OPRK1OGFRL1 | |
| SCHEMBL2030741 | 0.72 | L3MBTL1 (0.57) | OPRM1OPRK1OGFRL1L3MBTL1NPC1 | |
| SCHEMBL2362447 | 0.71 | NPC1 (0.46) | SMN1; SMN2L3MBTL1NPC1PKMNFKB1 | |
| SCHEMBL2360920 | 0.71 | HCAR1 (0.50) | RORCOPRM1OPRK1OGFRL1L3MBTL1 | |
| SCHEMBL21310845 | 0.70 | HCAR1 (0.50) | OPRM1OPRK1OGFRL1L3MBTL1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170114022-A1 | BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS | CHANNEL BIOSCIENCES, LLC | 2017-04-27 | — | — | US | disclosed |
| US-20170114022-A1 | BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS | CHANNEL BIOSCIENCES, LLC | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114022-A1 | BENZOIMIDAZOL-1,2-YL AMIDES AS Kv7 CHANNEL ACTIVATORS | KCNA7, KCNJ2, KCNK17 | RORC 3620/4885MET 4818/4885ALK 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.