SCHEMBL1878124

SCHEMBL1878124

CC1Cc2cc(O)c(CCO)cc2N1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CREBBP Q92793 4/20 0.37
LMNA P02545 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
ESR1 P03372 2/20 0.36
ESR2 Q92731 2/20 0.36
AR P10275 2/20 0.34
PGR P06401 1/20 0.34
FYN P06241 2/20 0.33
NNMT P40261 2/20 0.31
BRD4 O60885 3/20 0.30
TSHR P16473 2/20 0.30
DRD2 P14416 2/20 0.30
EP300 Q09472 2/20 0.30
MAOA P21397 1/20 0.30
KDM4E B2RXH2 1/20 0.30
CYP2C9 P11712 1/20 0.30
DRD3 P35462 1/20 0.30
HIF1A Q16665 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1878747 0.80 LMNA (0.42) CREBBPLMNAGAAMAPTAR
SCHEMBL1884351 0.78 LMNA (0.40) CREBBPLMNAGAAMAPTESR1
SCHEMBL14234586 0.75 MAPT (0.39) CREBBPLMNAGAAMAPTAR
SCHEMBL12965849 0.73 AR (0.45) CREBBPLMNAGAAMAPTAR
SCHEMBL12965982 0.71 AR (0.44) CREBBPLMNAGAAMAPTAR
SCHEMBL1878123 0.70 LMNA (0.36) CREBBPLMNAGAAMAPTAR
SCHEMBL15311620 0.69 AR (0.43) CREBBPLMNAGAAMAPTAR
SCHEMBL20156702 0.68 LMNA (0.49) CREBBPLMNAGAAMAPTESR1
SCHEMBL19289729 0.68 LMNA (0.49) CREBBPLMNAGAAMAPTESR1
SCHEMBL7141402 0.67 AR (0.33) CREBBPLMNAGAAMAPTAR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103517703-B Stain and application thereof 天野酶制品株式会社 2016-11-09 CN claimed
EP-2623093-B1 DYE FOR KERATIN FIBERS USING BILIRUBIN OXIDASE AND INDOLE DERIVATIVES AMANO ENZYME INC (JP) 2016-05-25 EP claimed
US-20140359950-A1 DYEING OF KERATIN FIBERS USING INDOLE ANALOGUE AMANO ENZYME INC. (JP) 2014-12-11 US claimed
EP-2708223-B1 DYEING AGENT AND USE FOR SAME AMANO ENZYME INC (JP) 2017-02-01 EP disclosed
CN-103517703-B Stain and application thereof 天野酶制品株式会社 2016-11-09 CN disclosed
EP-3067041-A1 METHOD FOR DYEING KERATIN FIBERS, KERATIN FIBER DYE Shisei Chemical Co., Ltd. (JP) 2016-09-14 EP disclosed
US-9358198-B2 Dyeing of keratin fibers using indole analogue AMANO ENZYME INC. (JP) 2016-06-07 US disclosed
US-20140359950-A1 DYEING OF KERATIN FIBERS USING INDOLE ANALOGUE AMANO ENZYME INC. (JP) 2014-12-11 US disclosed
US-8740994-B2 Dyeing agent and use for same AMANO ENZYME INC. (JP) 2014-06-03 US disclosed
EP-2708223-A1 DYEING AGENT AND USE FOR SAME Amano Enzyme Inc. (JP) 2014-03-19 EP disclosed
US-20140068875-A1 DYEING AGENT AND USE FOR SAME AMANO ENZYME INC (JP) 2014-03-13 US disclosed
EP-1533371-A1 CULTURE HAVING PHENOL OXIDASE-LIKE ACTIVITY Mandom Corporation (JP) 2005-05-25 EP disclosed
US-20030106166-A1 Compositions for dyeing keratinous fiber LION CORPORATION (JP) 2003-06-12 US disclosed
US-20030074743-A1 Hair dye composition LION CORPORATION (JP) 2003-04-24 US disclosed
EP-1240890-A1 HAIR DYE COMPOSITION Lion Corporation (JP) 2002-09-18 EP disclosed
EP-1234569-A1 COMPOSITIONS FOR DYEING HORNY FIBERS Lion Corporation (JP) 2002-08-28 EP disclosed
EP-1189576-A2 HAIR COMPOSITION COMPRISING AN OXIDASE AND CYCLODEXTRIN Lion Corporation (JP) 2002-03-27 EP disclosed
EP-1142561-A1 HAIR DYE COMPOSITIONS Lion Corporation (JP) 2001-10-10 EP disclosed
EP-1142562-A1 HAIR DYE COMPOSITIONS Lion Corporation (JP) 2001-10-10 EP disclosed
WO-2001000144-A2 HAIR COMPOSITION COMPRISING AN OXIDASE AND CYCLODEXTRIN LION CORPORATION (JP) 2001-01-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030106166-A1 Compositions for dyeing keratinous fiber KRT18, LPO, CKMT1A; CKMT1B CREBBP 3239/4885LMNA 1860/4885GAA 745/4885
US-20030074743-A1 Hair dye composition HAAO, GRHPR, CD44 CREBBP 4285/4885LMNA 3302/4885GAA 414/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.