Sugi Predict

Sugi Predict / Compounds / SCHEMBL1879154

SCHEMBL1879154

SCHEMBL1879154

O=C(O)c1ccc(OCCF)cc1

nearest known ligand 0.69

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ PKM P14618 1/20 0.69
▸ MAPK1 P28482 2/20 0.61
▸ TSHR P16473 2/20 0.61
▸ TP53 P04637 1/20 0.61
▸ PLA2G4B P0C869 4/20 0.59
▸ ALDH1A1 P00352 2/20 0.59
▸ L3MBTL1 Q9Y468 1/20 0.59
▸ USP2 O75604 1/20 0.57
▸ ALOX15 P16050 1/20 0.57
▸ HSD17B10 Q99714 1/20 0.57
▸ RARB P10826 4/20 0.56
▸ HTT P42858 1/20 0.56
▸ NR4A2 P43354 2/20 0.55
▸ NR4A1 P22736 1/20 0.55
▸ NR4A3 Q92570 1/20 0.55
▸ GAA P10253 1/20 0.53
▸ PLA2G4A P47712 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12615430 0.90 PKM (0.67) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL22495487 0.89 PKM (0.66) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL22495314 0.89 PKM (0.66) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL28688334 0.89 TP53 (0.67) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL1797153 0.89 PKM (0.65) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL196110 0.87 PKM (0.88) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL77587 0.86 PKM (0.71) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL1952122 0.85 TP53 (0.79) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL118037 0.85 PKM (0.77) PKMMAPK1TSHRTP53PLA2G4B
SCHEMBL222598 0.84 PKM (0.69) PKMMAPK1TSHRTP53PLA2G4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 — — US disclosed
EP-3856178-B1 MONOACYLGLYCEROL LIPASE MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2026-03-11 — — EP disclosed
EP-4633683-A1 CYCLOOCTENE COMPOSITIONS AND USES THEREOF Biogen MA Inc. (US) 2025-10-22 — — EP disclosed
EP-3728234-B1 RADIOLABELED COMPOUNDS HOFFMANN LA ROCHE (CH) 2025-05-14 — — EP disclosed
EP-3551631-B9 NON-PEPTIDE OXYTOCIN RECEPTOR AGONISTS Kinoxis Therapeutics Pty Ltd (AU) 2025-02-26 — — EP disclosed
EP-4494705-A2 NON-PEPTIDE OXYTOCIN RECEPTOR AGONISTS Kinoxis Therapeutics Pty Ltd (AU) 2025-01-22 — — EP disclosed
EP-3551631-B1 NON-PEPTIDE OXYTOCIN RECEPTOR AGONISTS Kinoxis Therapeutics Pty Ltd (AU) 2024-11-13 — — EP disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 — — CN disclosed
WO-2024130105-A1 CYCLOOCTENE COMPOSITIONS AND USES THEREOF BIOGEN MA INC. (US) 2024-06-20 — — WO disclosed
WO-2024130105-A1 CYCLOOCTENE COMPOSITIONS AND USES THEREOF BIOGEN MA INC. (US) 2024-06-20 — — WO disclosed
EP-1756087-B1 AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE WYETH CORP (US) 2009-10-07 — — EP disclosed
US-20090093498-A1 AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE WYETH (US) 2009-04-09 — — US disclosed
US-20090093498-A1 AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE WYETH (US) 2009-04-09 — — US disclosed
US-7482349-B2 Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase WYETH (US) 2009-01-27 — — US disclosed
US-7482349-B2 Amino-5,5-diphenylimidazolone derivatives for the inhibition of β-secretase WYETH (US) 2009-01-27 — — US disclosed
US-20080119422-A1 Indole Derivatives MITSUBISHI TANABE PHARMA CORPORATION (JP) 2008-05-22 — — US disclosed
EP-1756087-A1 AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE Wyeth (US) 2007-02-28 — — EP disclosed
US-20060199806-A1 Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists WYETH (US) 2006-09-07 — — US disclosed
WO-2006009653-A1 AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE WYETH (US) 2006-01-26 — — WO disclosed
US-20050282825-A1 Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase WYETH (US) 2005-12-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH PKM 2203/4885MAPK1 4010/4885TSHR 400/4885
US-20090093498-A1 AMINO-5,5-DIPHENYLIMIDAZOLONE DERIVATIVES FOR THE INHIBITION OF BETA-SECRETASE BACE1, BACE2, APP PKM 3219/4885MAPK1 2942/4885TSHR 4786/4885
US-20050282825-A1 Amino-5,5-diphenylimidazolone derivatives for the inhibition of beta-secretase BACE1, BACE2, APP PKM 3219/4885MAPK1 2942/4885TSHR 4786/4885
US-20060199806-A1 Pyrrolobenzodiazepine arylcarboxamides and derivatives thereof as follicle-stimulating hormone receptor antagonists FSHR, GNRHR, LHCGR PKM 4039/4885MAPK1 3621/4885TSHR 19/4885
US-20080119422-A1 Indole Derivatives IDO1, TPH1, NAT1 PKM 3680/4885MAPK1 1251/4885TSHR 62/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.