Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | TERT | O14746 | 3/20 | 0.41 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.41 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.41 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.41 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.41 |
| ▸ | P2RY6 | Q15077 | 6/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | P2RY2 | P41231 | 7/20 | 0.39 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1879256 | 1.00 | DUT (0.65) | DUTLMNAALDH1A1ALBPOLB | |
| SCHEMBL8540687 | 0.99 | DUT (0.64) | DUTLMNAALDH1A1ALBPOLB | |
| SCHEMBL1884831 | 0.85 | DUT (0.58) | DUTLMNAALDH1A1ALBPOLB | |
| SCHEMBL1884832 | 0.85 | DUT (0.58) | DUTLMNAALDH1A1ALBPOLB | |
| SCHEMBL9083433 | 0.81 | ALDH1A1 (0.69) | LMNAALDH1A1ALBPOLBADRA1A | |
| SCHEMBL543444 | 0.80 | ALDH1A1 (0.60) | DUTLMNAALDH1A1ALBPOLB | |
| SCHEMBL543443 | 0.80 | ALDH1A1 (0.60) | DUTLMNAALDH1A1ALBPOLB | |
| SCHEMBL4276828 | 0.80 | LMNA (0.51) | DUTLMNAALDH1A1ALBPOLB | |
| SCHEMBL9216504 | 0.79 | DUT (1.00) | DUTLMNAALDH1A1ALBPOLB | |
| SCHEMBL3582941 | 0.75 | DUT (0.61) | DUTLMNAALDH1A1ALBPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394934-B2 | Method and process for synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides | HUANG, ZHEN, DR. | 2013-03-12 | — | — | US | disclosed |
| US-20110105743-A1 | IMPROVED METHOD AND PROCESS FOR SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES | HUANG, ZHEN, DR. | 2011-05-05 | — | — | US | disclosed |
| WO-2009117668-A1 | IMPROVED METHOD AND PROCESS FOR SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES | HUANG ZHEN (US) | 2009-09-24 | — | — | WO | disclosed |
| US-5410033-A | Deoxygenation of cis vicinal diols to make didehydro dideoxy nucleosidies and synthetic intermediates | TEROCHEM LABORATORIES LIMITED (CA) | 1995-04-25 | — | — | US | disclosed |
| EP-0261595-B1 | PHARMACEUTICAL COMPOSITION COMPRISING 2',3'-DIDEOXYCYTIDIN-2'-ENE(2',3'-DIDEHYDROCYTIDINE) FOR TREATING PATIENTS INFECTED WITH RETROVIRUS | YALE UNIVERSITY (US) | 1992-09-02 | — | — | EP | disclosed |
| US-5106962-A | Reacting nucleosides with viologens in the presence of base | AJINOMOTO CO., INC. (JP) | 1992-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105743-A1 | IMPROVED METHOD AND PROCESS FOR SYNTHESIS OF 2',3'-DIDEHYDRO-2',3'-DIDEOXYNUCLEOSIDES | DUT, DERA, UNG | DUT 1/4885LMNA 2507/4885ALDH1A1 1382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.