SCHEMBL543443

SCHEMBL543443

O=c1ccn([C@H]2C=C[C@@H](CO)O2)c(=O)[nH]1

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.60
LMNA P02545 1/20 0.60
ALB P02768 1/20 0.60
POLB P06746 1/20 0.60
ADRA1A P35348 1/20 0.60
BLM P54132 1/20 0.60
DUT P33316 1/20 0.60
SLC28A1 O00337 1/20 0.53
SLC28A2 O43868 1/20 0.53
SLC29A1 Q99808 1/20 0.53
SLC28A3 Q9HAS3 1/20 0.53
P2RY2 P41231 11/20 0.41
P2RY6 Q15077 9/20 0.39
P2RY4 P51582 4/20 0.39
P2RY14 Q15391 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL543444 1.00 ALDH1A1 (0.60) ALDH1A1LMNAALBPOLBADRA1A
SCHEMBL1879256 0.80 DUT (0.65) ALDH1A1LMNAALBPOLBADRA1A
SCHEMBL1879258 0.80 DUT (0.65) ALDH1A1LMNAALBPOLBADRA1A
SCHEMBL8540687 0.79 DUT (0.64) ALDH1A1LMNAALBPOLBADRA1A
SCHEMBL1884831 0.78 DUT (0.58) ALDH1A1LMNAALBPOLBADRA1A
SCHEMBL1884832 0.78 DUT (0.58) ALDH1A1LMNAALBPOLBADRA1A
SCHEMBL10015801 0.77 DUT (0.54) ALDH1A1LMNAALBPOLBADRA1A
SCHEMBL9216504 0.76 DUT (1.00) ALDH1A1LMNAALBPOLBADRA1A
Stavudine SCHEMBL3234890 0.75 ALDH1A1 (1.00) ALDH1A1LMNAALBPOLBADRA1A
Stavudine SCHEMBL8540086 0.75 ALDH1A1 (1.00) ALDH1A1LMNAALBPOLBADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US claimed
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2024-05-02 US claimed
EP-4045504-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS Ai-biopharma (FR) 2022-08-24 EP claimed
WO-2021074443-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2021-04-22 WO claimed
US-8110676-B2 Prodrugs activated by RNA-dependent DNA-polymerases PROTERA S.R.L. (IT) 2012-02-07 US claimed
US-20070259832-A1 Nucleotide mimics and their prodrugs BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2007-11-08 US claimed
EP-1485395-A2 NUCLEOTIDE MIMICS AND THEIR PRODRUGS Biota, Inc. (US) 2004-12-15 EP claimed
US-20040059104-A1 Nucleotide mimics and their prodrugs BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2004-03-25 US claimed
WO-2003072757-A2 NUCLEOTIDE MIMICS AND THEIR PRODRUGS BIOTA, INC. (US) 2003-09-04 WO claimed
EP-0377846-A1 Pharmaceutical mixture preparation containing nucleoside derivatives and pentosan polysulfate, and its manufacture and use HOECHST AKTIENGESELLSCHAFT (DE) 1990-07-18 EP claimed
JP-7145058-A None JP disclosed
JP-5097847-A None JP disclosed
JP-4077485-A None JP disclosed
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS AI-BIOPHARMA (FR) 2026-05-28 US disclosed
US-12539332-B2 Anti-viral and hepatic-targeted drugs A-BIOPHARMA (FR) 2026-02-03 US disclosed
US-4962193-A ADSORPTION ON POROUS NON-POLAR RESIN, THEN SEPARATION AND ELUTION AJINOMOTO CO., INC. (JP) 1990-10-09 US disclosed
EP-0377846-A1 Pharmaceutical mixture preparation containing nucleoside derivatives and pentosan polysulfate, and its manufacture and use HOECHST AKTIENGESELLSCHAFT (DE) 1990-07-18 EP disclosed
US-4904770-A Production of 2',3'-dideoxy-2',3'-didehydronucleosides BRISTOL-MYERS COMPANY (US) 1990-02-27 US disclosed
EP-0334368-A2 Production of 2',3'-dideoxy-2',3'-Didehydronucleosides Bristol-Myers Squibb Company (US) 1989-09-27 EP disclosed
US-4835104-A Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides AJINOMOTO CO., INC., PATENT & LICENSING DEPARTMENT (JP) 1989-05-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070259832-A1 Nucleotide mimics and their prodrugs NUDT14, ENTPD5, MTAP ALDH1A1 2112/4885LMNA 3677/4885ALB 4137/4885
US-12539332-B2 Anti-viral and hepatic-targeted drugs HAVCR2, NR1H4, NR1H3 ALDH1A1 3548/4885LMNA 1280/4885ALB 3076/4885
US-20260144879-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS HAVCR2, NR1H4, NR1H3 ALDH1A1 2758/4885LMNA 1661/4885ALB 3481/4885
US-20040059104-A1 Nucleotide mimics and their prodrugs NUDT14, ENTPD5, MTAP ALDH1A1 2112/4885LMNA 3677/4885ALB 4137/4885
US-20240139325-A1 ANTI-VIRAL AND HEPATIC-TARGETED DRUGS SLC10A1, HAVCR2, HDGF ALDH1A1 2739/4885LMNA 2736/4885ALB 315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.