Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | RHOC | P08134 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10931313 | 0.89 | KDM4E (0.49) | PDK2KDM4ETACR1ALDH1A1MAOB | |
| SCHEMBL18794845 | 0.86 | PTGDR2 (0.50) | SLC13A3TACR1TDP1L3MBTL1FFAR4 | |
| SCHEMBL1815388 | 0.83 | ALDH1A1 (0.45) | PDK2KDM4EL3MBTL1ALDH1A1SCN9A | |
| SCHEMBL18794874 | 0.82 | PDK2 (0.48) | PDK2KDM4ESLC13A3TACR1ALDH1A1 | |
| SCHEMBL18794839 | 0.80 | PSEN1 (0.53) | PDK2KDM4ESLC13A3TACR1TDP1 | |
| SCHEMBL18794849 | 0.76 | SLC13A3 (0.40) | SLC13A3TDP1L3MBTL1FFAR4TLR8 | |
| SCHEMBL10932863 | 0.76 | KDM4E (0.71) | PDK2KDM4EALDH1A1MAOBAOC3 | |
| SCHEMBL6507086 | 0.75 | ALDH1A1 (0.68) | PDK2TDP1ALDH1A1MAOBAOC3 | |
| SCHEMBL2113930 | 0.73 | PPARD (0.52) | KDM4E | |
| SCHEMBL22289602 | 0.73 | TACR1 (0.53) | TACR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200181067-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2020-06-11 | — | — | US | disclosed |
| US-20200181067-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2020-06-11 | — | — | US | disclosed |
| US-10604476-B2 | Fluorinated amide derivatives and their uses as therapeutic agents | TRILLIUM THERAPEUTICS INC. (CA) | 2020-03-31 | — | — | US | disclosed |
| US-20180334425-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2018-11-22 | — | — | US | disclosed |
| EP-3368509-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | Trillium Therapeutics Inc. (CA) | 2018-09-05 | — | — | EP | disclosed |
| WO-2017070795-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017070795-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180334425-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | GRIN2A, ACHE, BDNF | PDK2 1936/4885KDM4E 3359/4885SLC13A3 1803/4885 |
| US-10604476-B2 | Fluorinated amide derivatives and their uses as therapeutic agents | GRIN2A, ACHE, BDNF | PDK2 1936/4885KDM4E 3359/4885SLC13A3 1803/4885 |
| US-20200181067-A1 | FLUORINATED AMIDE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | GRIN2A, ACHE, BDNF | PDK2 1936/4885KDM4E 3359/4885SLC13A3 1803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.