Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.31 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18797108 | 0.80 | SMN1; SMN2 (0.35) | ALDH1A1HPGDADORA1 | |
| SCHEMBL23628513 | 0.74 | CDK8 (0.30) | CDK8ACVR1 | |
| SCHEMBL1679887 | 0.72 | ERCC1 (0.49) | CDK8ACVR1ALDH1A1FEN1ERCC1 | |
| SCHEMBL17224805 | 0.71 | PLA2G10 (0.38) | CDK8ACVR1ALDH1A1PLA2G10 | |
| SCHEMBL469635 | 0.70 | KDM4E (0.39) | CDK8ACVR1ALDH1A1HPGD | |
| SCHEMBL3789703 | 0.69 | MAPK8 (0.38) | CDK8ACVR1ALDH1A1HPGD | |
| SCHEMBL18131563 | 0.68 | CDK8 (0.34) | CDK8ACVR1ALDH1A1HPGD | |
| SCHEMBL24252130 | 0.68 | L3MBTL1 (0.35) | CDK8ACVR1 | |
| SCHEMBL18797105 | 0.68 | GAA (0.35) | CDK8ACVR1ALDH1A1HTR1AHPGD | |
| SCHEMBL11965000 | 0.68 | CDK8 (0.44) | CDK8ACVR1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3368523-B1 | NOVEL PYRIDAZINONE HERBICIDES | FMC CORP (US) | 2021-07-14 | — | — | EP | claimed |
| CN-108495849-B | Pyridazinone herbicides | FMC公司 | 2020-11-10 | — | — | CN | claimed |
| EP-3368523-A1 | NOVEL PYRDAZINONE HERBICIDES | E. I. du Pont de Nemours and Company (US) | 2018-09-05 | — | — | EP | claimed |
| WO-2017074992-A1 | NOVEL PYRDAZINONE HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-05-04 | — | — | WO | claimed |
| EP-3368523-B1 | NOVEL PYRIDAZINONE HERBICIDES | FMC CORP (US) | 2021-07-14 | — | — | EP | disclosed |
| CN-108495849-B | Pyridazinone herbicides | FMC公司 | 2020-11-10 | — | — | CN | disclosed |
| US-10750743-B2 | Pyridazinone herbicides | FMC CORPORATION (US) | 2020-08-25 | — | — | US | disclosed |
| US-20180332851-A1 | NOVEL PYRIDAZINONE HERBICIDES | FMC CORPORATION | 2018-11-22 | — | — | US | disclosed |
| EP-3368523-A1 | NOVEL PYRDAZINONE HERBICIDES | E. I. du Pont de Nemours and Company (US) | 2018-09-05 | — | — | EP | disclosed |
| WO-2017074992-A1 | NOVEL PYRDAZINONE HERBICIDES | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2017-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10750743-B2 | Pyridazinone herbicides | PRDX4, PRDX6, PDXK | CDK8 970/4885ACVR1 2087/4885ALDH1A1 1085/4885 |
| US-20180332851-A1 | NOVEL PYRIDAZINONE HERBICIDES | PRDX4, PRDX6, PDXK | CDK8 972/4885ACVR1 2347/4885ALDH1A1 1261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.