Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 3/20 | 0.61 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800468 | 0.89 | BTK (0.49) | BTKADORA2AADORA1DHODHHSD17B10 | |
| SCHEMBL18800563 | 0.86 | BTK (0.58) | BTKADORA2AADORA1HSD17B10MAPT | |
| SCHEMBL18800466 | 0.83 | DHODH (0.42) | BTKADORA2AADORA1DHODHHSD17B10 | |
| SCHEMBL18800786 | 0.81 | RAPGEF4 (0.44) | BTKADORA2AADORA1DHODHHSD17B10 | |
| SCHEMBL18800792 | 0.80 | BTK (0.47) | BTKADORA2AADORA1DHODHMAPT | |
| SCHEMBL18800891 | 0.79 | BTK (0.62) | BTKADORA2AADORA1DHODHMAPT | |
| SCHEMBL18800784 | 0.78 | BTK (0.46) | BTKADORA2AADORA1DHODH | |
| SCHEMBL18800559 | 0.78 | BTK (0.58) | BTKMAPTMAPK1TP53SRC | |
| SCHEMBL8402235 | 0.76 | BTK (0.75) | BTKADORA2AADORA1MAPTTP53 | |
| SCHEMBL18800772 | 0.76 | ADORA1 (0.43) | BTKADORA1HSD17B10MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |