Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 2/20 | 0.58 |
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PKLR | P30613 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | STAT1 | P42224 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800885 | 0.91 | BTK (0.48) | BTKSRCPDE11AALDH1A1MAPK10 | |
| SCHEMBL18800558 | 0.89 | BTK (0.43) | BTKPDE11AALDH1A1KMT2AMAPK10 | |
| SCHEMBL18800468 | 0.89 | BTK (0.49) | BTKSRCPDE11AALDH1A1MAPT | |
| SCHEMBL18800886 | 0.84 | BTK (0.42) | BTKNPC1SMN1; SMN2CSF1R | |
| SCHEMBL18800884 | 0.83 | BTK (0.42) | BTKNPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL18800792 | 0.81 | BTK (0.47) | BTKMAPK10MAPT | |
| SCHEMBL18800772 | 0.81 | ADORA1 (0.43) | BTKSRCPDE11AALDH1A1KMT2A | |
| SCHEMBL18800891 | 0.80 | BTK (0.62) | BTKALDH1A1KMT2AMAPTTP53 | |
| SCHEMBL18800784 | 0.79 | BTK (0.46) | BTK | |
| SCHEMBL18800466 | 0.79 | DHODH (0.42) | BTKSRCALDH1A1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |