Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BRD2 | P25440 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800468 | 0.90 | BTK (0.49) | BTKPDGFRBFGFR1PDGFRADHODH | |
| SCHEMBL18800891 | 0.88 | BTK (0.62) | BTKDHODHMAPTADORA2AADORA1 | |
| SCHEMBL18800784 | 0.87 | BTK (0.46) | BTKDHODHADORA2AADORA1PDE10A | |
| SCHEMBL18800772 | 0.85 | ADORA1 (0.43) | BTKLMNAGAAMAPK10BRD4 | |
| SCHEMBL18800558 | 0.84 | BTK (0.43) | BTKLMNAMAPK10 | |
| SCHEMBL18800885 | 0.82 | BTK (0.48) | BTKFGFR1MAPK10 | |
| SCHEMBL18800559 | 0.81 | BTK (0.58) | BTKMAPK10MAPT | |
| SCHEMBL18800466 | 0.81 | DHODH (0.42) | BTKPDGFRBFGFR1PDGFRADHODH | |
| SCHEMBL18800760 | 0.80 | BTK (0.61) | BTKPDGFRBFGFR1PDGFRADHODH | |
| SCHEMBL18800884 | 0.79 | BTK (0.42) | BTKLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |