Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.46 |
| ▸ | DHODH | Q02127 | 4/20 | 0.43 |
| ▸ | POLQ | O75417 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800468 | 0.89 | BTK (0.49) | BTKDHODHADORA2AADORA1 | |
| SCHEMBL18800792 | 0.87 | BTK (0.47) | BTKDHODHADORA2AADORA1PDE10A | |
| SCHEMBL18800891 | 0.86 | BTK (0.62) | BTKDHODHADORA2AADORA1F10 | |
| SCHEMBL18800772 | 0.83 | ADORA1 (0.43) | BTKADORA1 | |
| SCHEMBL18800558 | 0.83 | BTK (0.43) | BTK | |
| SCHEMBL18800885 | 0.81 | BTK (0.48) | BTK | |
| SCHEMBL18800559 | 0.79 | BTK (0.58) | BTK | |
| SCHEMBL18800466 | 0.79 | DHODH (0.42) | BTKDHODHADORA2AADORA1 | |
| SCHEMBL18800760 | 0.78 | BTK (0.61) | BTKDHODHADORA2AADORA1 | |
| SCHEMBL18800884 | 0.78 | BTK (0.42) | BTKPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |