Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.62 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 2/20 | 0.35 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | PLAU | P00749 | 2/20 | 0.35 |
| ▸ | PLAT | P00750 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800468 | 0.89 | BTK (0.49) | BTKDHODHADORA2AADORA1MAPT | |
| SCHEMBL18800792 | 0.88 | BTK (0.47) | BTKDHODHPDE10AADORA2AADORA1 | |
| SCHEMBL18800784 | 0.86 | BTK (0.46) | BTKDHODHPDE10AADORA2AADORA1 | |
| SCHEMBL18800772 | 0.84 | ADORA1 (0.43) | BTKMEN1KMT2AADORA1MAPT | |
| SCHEMBL18800558 | 0.84 | BTK (0.43) | BTKMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL18800885 | 0.81 | BTK (0.48) | BTKF2PLGPLAUPRSS1 | |
| SCHEMBL18800559 | 0.80 | BTK (0.58) | BTKMEN1KMT2ATSHRMAPT | |
| SCHEMBL18800466 | 0.80 | DHODH (0.42) | BTKDHODHMEN1KMT2ATSHR | |
| SCHEMBL18800760 | 0.79 | BTK (0.61) | BTKDHODHPLAUADORA2AADORA1 | |
| SCHEMBL18800884 | 0.78 | BTK (0.42) | BTKTSHRTP53SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |