Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 4/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800466 | 0.90 | DHODH (0.42) | BTKADORA2AADORA1HSD17B10CYP1A2 | |
| SCHEMBL18800792 | 0.90 | BTK (0.47) | BTKADORA2AADORA1MAPTDHODH | |
| SCHEMBL18800891 | 0.89 | BTK (0.62) | BTKADORA2AADORA1MAPTRXFP1 | |
| SCHEMBL18800760 | 0.89 | BTK (0.61) | BTKADORA2AADORA1HSD17B10CYP1A2 | |
| SCHEMBL18800559 | 0.89 | BTK (0.58) | BTKMAPK1MAPTSRCPDE11A | |
| SCHEMBL18800784 | 0.89 | BTK (0.46) | BTKADORA2AADORA1DHODH | |
| SCHEMBL18800563 | 0.87 | BTK (0.58) | BTKADORA2AADORA1HSD17B10CYP1A2 | |
| SCHEMBL18800772 | 0.87 | ADORA1 (0.43) | BTKADORA1HSD17B10MAPTSRC | |
| SCHEMBL18800558 | 0.86 | BTK (0.43) | BTKHSD17B10PDE11AALDH1A1LMNA | |
| SCHEMBL18800786 | 0.86 | RAPGEF4 (0.44) | BTKADORA2AADORA1HSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |