Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16168176 | 0.91 | BTK (0.46) | BTKSCN9A | |
| SCHEMBL18800883 | 0.86 | MAPK14 (0.40) | BTKSCN9ASMN1; SMN2LMNAOPRM1 | |
| SCHEMBL18800565 | 0.86 | BTK (0.61) | BTKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18800771 | 0.85 | BTK (0.39) | BTKOPRM1OPRD1OPRK1 | |
| SCHEMBL18800753 | 0.84 | BTK (0.49) | BTKSCN9A | |
| SCHEMBL18800492 | 0.83 | BTK (0.48) | BTKSCN9A | |
| SCHEMBL18800616 | 0.82 | BTK (0.47) | BTKSCN9A | |
| SCHEMBL18800747 | 0.81 | KMT2A (0.46) | BTKNPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL18800564 | 0.81 | BTK (0.47) | BTKSCN9ANPC1RAB9ALMNA | |
| SCHEMBL18800751 | 0.79 | BTK (0.46) | BTKPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |