Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.61 |
| ▸ | PGR | P06401 | 3/20 | 0.51 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.39 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.39 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800753 | 0.86 | BTK (0.49) | BTK | |
| SCHEMBL18800768 | 0.86 | BTK (0.45) | BTKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18800492 | 0.85 | BTK (0.48) | BTK | |
| SCHEMBL18800616 | 0.84 | BTK (0.47) | BTK | |
| SCHEMBL18800747 | 0.83 | KMT2A (0.46) | BTKHPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL18800564 | 0.83 | BTK (0.47) | BTKNPC1RAB9A | |
| SCHEMBL18800615 | 0.82 | BTK (0.62) | BTKPGRNPC1RAB9A | |
| SCHEMBL18800751 | 0.82 | BTK (0.46) | BTKATR | |
| SCHEMBL18800757 | 0.81 | TNK2 (0.49) | BTK | |
| SCHEMBL16168177 | 0.81 | PARP10 (0.51) | BTKCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |