Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 10/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | AKT2 | P31751 | 1/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18800883 | 0.86 | MAPK14 (0.40) | BTKOPRM1OPRD1OPRK1 | |
| SCHEMBL18800753 | 0.85 | BTK (0.49) | BTKTNK2 | |
| SCHEMBL18800768 | 0.85 | BTK (0.45) | BTKOPRM1OPRD1OPRK1 | |
| SCHEMBL18800492 | 0.84 | BTK (0.48) | BTKTNK2 | |
| SCHEMBL18800616 | 0.83 | BTK (0.47) | BTKTNK2 | |
| SCHEMBL18800747 | 0.82 | KMT2A (0.46) | BTKTNK2 | |
| SCHEMBL18800564 | 0.82 | BTK (0.47) | BTKTNK2 | |
| SCHEMBL18800575 | 0.80 | BTK (0.45) | BTKTNK2 | |
| SCHEMBL16168177 | 0.79 | PARP10 (0.51) | BTKTNK2 | |
| SCHEMBL18800757 | 0.79 | TNK2 (0.49) | BTKTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2789615-B1 | Azaindazoles as Btk kinase modulators and use thereof | BRISTOL MYERS SQUIBB CO (US) | 2017-05-03 | — | — | EP | disclosed |