Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.60 |
| ▸ | MTNR1A | P48039 | 14/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8575276 | 0.92 | MTNR1A (0.63) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL1903920 | 0.84 | MTNR1A (0.58) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL16232221 | 0.82 | MTNR1A (0.56) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL12405342 | 0.82 | NQO2 (0.58) | MTNR1ANQO2 | |
| SCHEMBL14724998 | 0.81 | HTR2A (0.60) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL27950864 | 0.80 | MTNR1A (0.67) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL827963 | 0.79 | HTR2A (0.70) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL124258 | 0.79 | MTNR1A (0.65) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL12013659 | 0.79 | HTR2A (0.65) | HTR2AMTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL14861608 | 0.79 | MTNR1A (0.52) | HTR2AMTNR1AMTNR1BHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9604911-B2 | Process for the synthesis of agomelatine | LES LABORATOIRES SERVIER (FR) | 2017-03-28 | — | — | US | disclosed |
| US-20160368859-A1 | PROCESS FOR THE SYNTHESIS OF AGOMELATINE | LES LABORATOIRES SERVIER (FR) | 2016-12-22 | — | — | US | disclosed |
| EP-2703383-A1 | Process for the preparation of agomelatine | Procos S.p.A. (IT) | 2014-03-05 | — | — | EP | disclosed |
| EP-2703383-A1 | Process for the preparation of agomelatine | Procos S.p.A. (IT) | 2014-03-05 | — | — | EP | disclosed |
| US-8653281-B2 | Process for the manufacture of agomelatine and its intermediate | NHWA PHARMA. CORPORATION (CN) | 2014-02-18 | — | — | US | disclosed |
| EP-2322508-B1 | PROCESS FOR THE MANUFACTURE OF AGOMELATINE AND ITS INTERMEDIATE | NHWA PHARMA CORP (CN) | 2013-01-02 | — | — | EP | disclosed |
| US-7947852-B2 | Naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2011-05-24 | — | — | US | disclosed |
| US-20100168244-A1 | NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LESS LABORATOIRES SERVIER (FR) | 2010-07-01 | — | — | US | disclosed |
| US-20100137446-A1 | NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LES LABORATOIRES SERVIER (FR) | 2010-06-03 | — | — | US | disclosed |
| EP-2167460-A2 | NOVEL NAPHTHALENE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2010-03-31 | — | — | EP | disclosed |
| EP-2167457-A2 | NOVEL NAPHTHALENE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2009022063-A2 | NOVEL NAPHTHALENE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-02-19 | — | — | WO | disclosed |
| WO-2009022064-A2 | NOVEL NAPHTHALENE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-02-19 | — | — | WO | disclosed |
| WO-2009022066-A2 | NOVEL NAPHTHALENE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2009-02-19 | — | — | WO | disclosed |
| US-5760071-A | AN UREA OR THIOUREA COMPOUNDS FOR TREATING MELATONINERGIC SYSTEM DISORDER, SLEEP DISORDER | ADIR ET COMPAGNIE (FR) | 1998-06-02 | — | — | US | disclosed |
| US-5731352-A | THERAPY FOR DISORDERS OF THE MELATONINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1998-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160368859-A1 | PROCESS FOR THE SYNTHESIS OF AGOMELATINE | COMT, PNMT, TPH1 | HTR2A 45/4885MTNR1A 232/4885MTNR1B 177/4885 |
| US-20100137446-A1 | NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MTNR1A, MTNR1B, AHR | HTR2A 26/4885MTNR1A 1/4885MTNR1B 2/4885 |
| US-20100168244-A1 | NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MTNR1A, MTNR1B, CYP11B2 | HTR2A 16/4885MTNR1A 1/4885MTNR1B 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.