Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD1 | P11586 | 2/20 | 0.86 |
| ▸ | DHFR | P00374 | 1/20 | 0.81 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.69 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | FPGS | Q05932 | 2/20 | 0.61 |
| ▸ | TYMS | P04818 | 1/20 | 0.58 |
| ▸ | ATIC | P31939 | 3/20 | 0.57 |
| ▸ | GART | P22102 | 6/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levomefolic Acid SCHEMBL30051011 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL2693607 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL29422840 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL31173596 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL7678398 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL79039 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL29616390 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL258787 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL4727836 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA | |
| Levomefolic Acid SCHEMBL30828726 | 1.00 | MTHFD1 (0.86) | MTHFD1DHFRSOSTMTHFD2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 196 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109939077-B | Controlled release preparation containing 5-methyltetrahydrofolic acid | 深圳奥萨制药有限公司 | 2022-07-22 | — | — | CN | claimed |
| CN-109864978-B | Sustained-release preparation of 5-methyltetrahydrofolic acid and preparation method thereof | 深圳奥萨制药有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-114340635-A | Application of 5-methyltetrahydrofolic acid | 连云港金康和信药业有限公司 | 2022-04-12 | — | — | CN | claimed |
| WO-2021043196-A1 | USE OF 5-METHYLTETRAHYDROFOLATE | 连云港金康和信药业有限公司 | 2021-03-11 | — | — | WO | claimed |
| CN-109939077-A | A kind of controlled release preparation containing 5-methyltetrahydrofolate | 深圳奥萨制药有限公司 | 2019-06-28 | — | — | CN | claimed |
| CN-109864978-A | A kind of sustained release preparation of 5-methyltetrahydrofolate and preparation method thereof | 深圳奥萨制药有限公司 | 2019-06-11 | — | — | CN | claimed |
| US-20180237781-A1 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2018-08-23 | — | — | US | claimed |
| CN-107892692-A | The preparation method and applications of (6S) 5 methyl tetrahydrofolate zinc salt | 华东理工大学 | 2018-04-10 | — | — | CN | claimed |
| WO-2016025750-A2 | COMPOSITIONS AND METHODS FOR REGULATION OF GENE EXPRESSION WITH, AND DETECTION OF, FOLINIC ACID AND FOLATES | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-02-18 | — | — | WO | claimed |
| EP-2245032-B1 | FOLATES, COMPOSITIONS AND USES THEREOF | GNOSIS SPA (IT) | 2015-03-25 | — | — | EP | claimed |
| EP-1044975-A1 | Stable crystalline salts of 5-methyltetrahydrofolic acid | EPROVA Aktiengesellschaft (CH) | 2000-10-18 | — | — | EP | claimed |
| US-5997915-A | NATURAL ISOMERS OF TETRAHYDROFOLIC ACID DERIVATIVES | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) | 1999-12-07 | — | — | US | claimed |
| EP-0877563-A4 | FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES | UNIV SOUTH ALABAMA (US) | 1999-06-09 | — | — | EP | claimed |
| CN-1209729-A | Food and vitamin products containing natural isomer of reduced folates | UNIV SOUTH ALABAMA (US) | 1999-03-03 | — | — | CN | claimed |
| EP-0877563-A1 | FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES | South Alabama Medical Science Foundation (US) | 1998-11-18 | — | — | EP | claimed |
| WO-1997027764-A1 | FOOD AND VITAMIN PREPARATIONS CONTAINING THE NATURAL ISOMER OF REDUCED FOLATES | SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION (US) | 1997-08-07 | — | — | WO | claimed |
| EP-0505640-B1 | Improved therapeutic method | LILLY CO ELI (US) | 1995-08-23 | — | — | EP | claimed |
| EP-0567324-A1 | Medicaments for treating gar-transformylase-dependent tumors | ELI LILLY AND COMPANY (US) | 1993-10-27 | — | — | EP | claimed |
| US-5217974-A | Administering enzyme inhibitor as antitumor agent with folic acid or its derivatives to reduce toxicity | ELI LILLY AND COMPANY (US) | 1993-06-08 | — | — | US | claimed |
| EP-0505640-A1 | Improved therapeutic method | ELI LILLY AND COMPANY (US) | 1992-09-30 | — | — | EP | claimed |