Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.70 |
| ▸ | CXCR2 | P25025 | 5/20 | 0.70 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.70 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.70 |
| ▸ | LMNA | P02545 | 2/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.70 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.70 |
| ▸ | ALB | P02768 | 1/20 | 0.70 |
| ▸ | ESR1 | P03372 | 1/20 | 0.70 |
| ▸ | RARB | P10826 | 1/20 | 0.70 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.70 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 1/20 | 0.70 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.70 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.70 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 1/20 | 0.70 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL260688 | 1.00 | EPHX1 (1.00) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| SCHEMBL3152241 | 1.00 | EPHX1 (1.00) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL3424822 | 0.98 | EPHX1 (0.96) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| SCHEMBL1082216 | 0.90 | EPHX1 (0.81) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| SCHEMBL11641216 | 0.85 | EPHX1 (0.74) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| SCHEMBL13802425 | 0.84 | EPHX1 (0.72) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| SCHEMBL4471196 | 0.82 | CXCR1 (0.79) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| Ibuprofen SCHEMBL239446 | 0.82 | PTGS1 (1.00) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| SCHEMBL1526008 | 0.82 | EPHX1 (0.70) | EPHX1CXCR1CXCR2PTGS1PTGS2 | |
| SCHEMBL22509339 | 0.82 | EPHX1 (0.70) | EPHX1CXCR1CXCR2PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6881755-B2 | N-(2-aryl-propionyl)-sulfonamides and pharmaceutical preparations containing them | Dompé S.p.A. (IT) | 2005-04-19 | — | — | US | claimed |
| US-20030216392-A1 | N - ( 2 - aryl - propionyl ) - sulfonamides and pharmaceutical preparations containing them | DOMPE S.P.A. | 2003-11-20 | — | — | US | claimed |
| EP-1123276-B1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE SPA (IT) | 2003-01-08 | — | — | EP | claimed |
| EP-1123276-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | Dompe' S.P.A. (IT) | 2001-08-16 | — | — | EP | claimed |
| WO-2000024710-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2000-05-04 | — | — | WO | claimed |
| US-8293788-B2 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2012-10-23 | — | — | US | disclosed |
| US-8293788-B2 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2012-10-23 | — | — | US | disclosed |
| US-20120004264-A1 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPÉ PHA.R.MA S.P.A. (IT) | 2012-01-05 | — | — | US | disclosed |
| US-20120004264-A1 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DOMPÉ PHA.R.MA S.P.A. (IT) | 2012-01-05 | — | — | US | disclosed |
| US-8039656-B2 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2011-10-18 | — | — | US | disclosed |
| US-8039656-B2 | 2-phenylpropionic acid derivatives and pharmaceutical compositions containing them | DOMPÉ FARMACEUTICI S.P.A. (IT) | 2011-10-18 | — | — | US | disclosed |
| US-7939521-B2 | 2-arylpropionic acid derivatives and pharmaceutical compositions containing them | DompePHA.R.MA S.p.A. (IT) | 2011-05-10 | — | — | US | disclosed |
| EP-1123276-B1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE SPA (IT) | 2003-01-08 | — | — | EP | disclosed |
| EP-1255726-A2 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8 INDUCED CHEMIOTAXIS OF NEUTROPHILS | Dompé S.P.A. (IT) | 2002-11-13 | — | — | EP | disclosed |
| EP-0759426-B1 | Process for the preparation of optically active 1-aryl-alkylamines | BAYER AG (DE) | 2001-11-28 | — | — | EP | disclosed |
| WO-2001058852-A2 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8-INDUCED CHEMIOTAXIS OF NEUTROPHILS | Dompé S.p.A. (IT) | 2001-08-16 | — | — | WO | disclosed |
| EP-1123276-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | Dompe' S.P.A. (IT) | 2001-08-16 | — | — | EP | disclosed |
| WO-2000024710-A1 | N-(2-ARYL-PROPIONYL)-SULFONAMIDES AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | DOMPE' S.P.A. (IT) | 2000-05-04 | — | — | WO | disclosed |
| US-5773656-A | Process for the preparation of optically active 1-aryl-alkylamines | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-30 | — | — | US | disclosed |
| EP-0759426-A2 | Process for the preparation of optically active 1-aryl-alkylamines | BAYER AG (DE) | 1997-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030216392-A1 | N - ( 2 - aryl - propionyl ) - sulfonamides and pharmaceutical preparations containing them | ELANE, MPO, FPR1 | EPHX1 1036/4885CXCR1 133/4885CXCR2 15/4885 |
| US-20120004264-A1 | 2-PHENYLPROPIONIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | CXCR2, CXCR3, MMP8 | EPHX1 1095/4885CXCR1 4/4885CXCR2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.