SCHEMBL188481

SCHEMBL188481

CCC(CC)=C(C#N)C(=O)O

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
FFAR3 O14843 1/20 0.36
GRIK1 P39086 1/20 0.33
GRIA4 P48058 1/20 0.33
GRIK3 Q13003 1/20 0.33
GRIK5 Q16478 1/20 0.33
ALDH1A1 P00352 3/20 0.31
TSHR P16473 1/20 0.31
TDP1 Q9NUW8 2/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19357539 0.87 FFAR3 (0.37) FFAR3ALDH1A1TSHR
SCHEMBL3923583 0.87 FFAR3 (0.37) FFAR3ALDH1A1TSHR
SCHEMBL19357480 0.83
SCHEMBL19357481 0.83
SCHEMBL7548122 0.83 GRIK1 (0.35) GRIK1GRIA4GRIK3GRIK5ALDH1A1
SCHEMBL7545293 0.83 CES1 (0.39) ALDH1A1TSHRTDP1
SCHEMBL8673175 0.82 AKR1B1 (0.43) ALDH1A1TSHRTDP1
SCHEMBL8673179 0.82 AKR1B1 (0.43) ALDH1A1TSHRTDP1
SCHEMBL8600596 0.81 HDAC3 (0.40) FFAR3ALDH1A1TSHRTDP1
SCHEMBL540776 0.80 GPR84 (0.45) ALDH1A1TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025110241-A1 METHOD FOR PRODUCING 1,1,2-TRISUBSTITUTED ETHANE AND METHOD FOR PRODUCING 1,1-DISUBSTITUTED OLEFIN 東亞合成株式会社 2025-05-30 WO disclosed
US-20250170117-A1 MODULATORS OF ACKR3 AND USES THEREOF INTERAX BIOTECH AG (CH) 2025-05-29 US disclosed
EP-4486739-A1 MODULATORS OF ACKR3 AND USES THEREOF InterAx Biotech AG (CH) 2025-01-08 EP disclosed
US-20240279234-A1 KINASE INHIBITORS AND RELATED METHODS OF USE UTI LIMITED PARTNERSHIP (CA) 2024-08-22 US disclosed
US-11999737-B2 Kinase inhibitors and related methods of use DUKE UNIVERSITY (US) 2024-06-04 US disclosed
WO-2023166190-A1 MODULATORS OF ACKR3 AND USES THEREOF INTERAX BIOTECH AG (CH) 2023-09-07 WO disclosed
CN-110911750-B High-voltage lithium ion battery electrolyte, additive and preparation method of additive 珠海市赛纬电子材料股份有限公司 2022-06-24 CN disclosed
US-20210155627-A1 KINASE INHIBITORS AND RELATED METHODS OF USE UTI LIMITED PARTNERSHIP (CA) 2021-05-27 US disclosed
US-10934291-B2 Kinase inhibitors and related methods of use DUKE UNIVERSITY (US) 2021-03-02 US disclosed
CN-110911750-A High-voltage lithium ion battery electrolyte, additive and preparation method of additive 珠海市赛纬电子材料股份有限公司 2020-03-24 CN disclosed
WO-2010099054-A2 SOLUBLE GUANYLATE CYCLASE ACTIVATORS MERCK SHARP & DOHME CORP. (US) 2010-09-02 WO disclosed
US-20100216764-A1 Soluble Guanylate Cyclase Activators MERCK SHARP & DOHME LLC 2010-08-26 US disclosed
EP-1832596-A1 Compounds of mono-carboxyl functionalised dialkylphosphine acids and other components CLARIANT INTERNATIONAL LTD. (CH) 2007-09-12 EP disclosed
EP-1483442-A2 NOVEL CATALYTIC ACTIVITIES OF OXIDOREDUCTASES FOR OXIDATION AND/OR BLEACHING Call, Krimhild (DE) 2004-12-08 EP disclosed
EP-1436371-A2 ENZYMATIC SYSTEMS FOR GENERATING ACTIVE OXYGEN SPECIES FOR REACTING WITH OTHER PRECURSORS TO OBTAIN OXIDATION AND/OR BLEACHING Call, Krimhild (DE) 2004-07-14 EP disclosed
WO-2003061550-A2 NOVEL CATALYTIC ACTIVITIES OF OXIDOREDUCTASES FOR OXIDATION AND/OR BLEACHING CALL, KRIMHILD (DE) 2003-07-31 WO disclosed
WO-2002099023-A2 ENZYMATIC SYSTEMS FOR GENERATING ACTIVE OXYGEN SPECIES FOR REACTING WITH OTHER PRECURSORS TO OBTAIN OXIDATION AND/OR BLEACHING CALL, KRIMHILD (DE) 2002-12-12 WO disclosed
EP-1012376-A2 OXIDATION AND BLEACHING SYSTEM WITH ENZYMATICALLY PRODUCED OXIDIZING AGENTS Blume, Hildegard (DE) 2000-06-28 EP disclosed
WO-1998059108-A2 OXIDATION AND BLEACHING SYSTEM WITH ENZYMATICALLY PRODUCED OXIDIZING AGENTS BLUME, HILDEGARD (DE) 1998-12-30 WO disclosed
US-4167568-A TREATMENT OF RESPIRATORY SYSTEM DISORDERS, ANTIHISTAMINES MAY & BAKER LIMITED (GB) 1979-09-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240279234-A1 KINASE INHIBITORS AND RELATED METHODS OF USE DAPK2, DAPK1, DAPK3 FFAR3 3656/4885GRIK1 1637/4885GRIA4 3539/4885
US-20250170117-A1 MODULATORS OF ACKR3 AND USES THEREOF ACKR3, PROKR2, PROKR1 FFAR3 82/4885GRIK1 407/4885GRIA4 1115/4885
US-10934291-B2 Kinase inhibitors and related methods of use DAPK2, DAPK1, DAPK3 FFAR3 3656/4885GRIK1 1637/4885GRIA4 3539/4885
US-11999737-B2 Kinase inhibitors and related methods of use DAPK2, DAPK1, DAPK3 FFAR3 3656/4885GRIK1 1637/4885GRIA4 3539/4885
US-20210155627-A1 KINASE INHIBITORS AND RELATED METHODS OF USE DAPK2, DAPK1, DAPK3 FFAR3 3656/4885GRIK1 1637/4885GRIA4 3539/4885
US-20100216764-A1 Soluble Guanylate Cyclase Activators GUCY1B1, GUCY1A1, GUCY1A2 FFAR3 657/4885GRIK1 1254/4885GRIA4 1539/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.