Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4346290 | 0.97 | CTSL (0.52) | CTSLCTSBCTSKJAK2JAK1 | |
| SCHEMBL11814690 | 0.92 | CTSL (0.57) | CTSLCTSBCTSKJAK2JAK1 | |
| SCHEMBL22449348 | 0.92 | CTSL (0.57) | CTSLCTSBCTSKJAK2JAK1 | |
| SCHEMBL8640188 | 0.92 | CTSL (0.57) | CTSLCTSBCTSKJAK2JAK1 | |
| SCHEMBL2700673 | 0.92 | CTSL (0.57) | CTSLCTSBCTSKJAK2JAK1 | |
| SCHEMBL18561604 | 0.88 | CTSL (0.46) | CTSLCTSBCTSKJAK2JAK1 | |
| SCHEMBL31093863 | 0.88 | — | — | |
| SCHEMBL24445851 | 0.86 | CTSL (0.44) | CTSLCTSBCTSKJAK2JAK1 | |
| SCHEMBL9425975 | 0.86 | CTSL (0.44) | CTSLCTSBCTSKJAK2JAK1 | |
| SCHEMBL28832774 | 0.86 | CTSL (0.57) | CTSLCTSBCTSKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3950692-A1 | NOVEL TRICYCLIC COMPOUNDS | AbbVie Inc. (US) | 2022-02-09 | — | — | EP | disclosed |
| EP-3636627-B1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | INT FLAVORS & FRAGRANCES INC (US) | 2021-12-15 | — | — | EP | disclosed |
| EP-3636627-B1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | INT FLAVORS & FRAGRANCES INC (US) | 2021-12-15 | — | — | EP | disclosed |
| US-11111458-B2 | Cyclopropylmethoxy derivatives | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2021-09-07 | — | — | US | disclosed |
| US-11111458-B2 | Cyclopropylmethoxy derivatives | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2021-09-07 | — | — | US | disclosed |
| CN-111018680-A | Novel cyclopropyl methoxy derivative | 国际香料和香精公司 | 2020-04-17 | — | — | CN | disclosed |
| US-20200115652-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2020-04-16 | — | — | US | disclosed |
| EP-3636627-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | International Flavors & Fragrances Inc. (US) | 2020-04-15 | — | — | EP | disclosed |
| US-9884860-B2 | Fused pyrroledicarboxamides and their use as pharmaceuticals | SANOFI (FR) | 2018-02-06 | — | — | US | disclosed |
| EP-2506716-B1 | NOVEL TRICYCLIC COMPOUNDS | ABBVIE INC (US) | 2017-05-17 | — | — | EP | disclosed |
| US-20160159793-A1 | Fused Pyrroledicarboxamides and Their Use as Pharmaceuticals | SANOFI (FR) | 2016-06-09 | — | — | US | disclosed |
| US-9284333-B2 | Fused pyrroledicarboxamides and their use as pharmaceuticals | SANOFI (FR) | 2016-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11111458-B2 | Cyclopropylmethoxy derivatives | TRPA1, TRPV1, CBR3 | CTSL 4305/4885CTSB 3084/4885CTSK 2908/4885 |
| US-20200115652-A1 | NOVEL CYCLOPROPYLMETHOXY DERIVATIVES | TRPA1, TRPV1, OR51E2 | CTSL 4431/4885CTSB 3642/4885CTSK 3423/4885 |
| US-20160159793-A1 | Fused Pyrroledicarboxamides and Their Use as Pharmaceuticals | KCNA1, KCNE1, KCNH1 | CTSL 3634/4885CTSB 4341/4885CTSK 3539/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.