SCHEMBL18857765

CC(C)C[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CNCN1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)O

nearest known ligand 0.51

Predicted protein targets (top 2)

	gene	UniProt	supporting neighbours	confidence
▸	GHSR	Q92847	9/20	0.51

▸	GRPR	P30550	2/20	0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18854331	0.94	GHSR (0.56)	GHSRGRPR
SCHEMBL18854323	0.89	GHSR (0.59)	GHSR
SCHEMBL18854269	0.87	GHSR (0.60)	GHSRGRPR
SCHEMBL18862362	0.83	REN (0.63)	—
SCHEMBL18857723	0.83	KISS1R (0.51)	GRPR
SCHEMBL18854322	0.82	IL23R (0.60)	GHSRGRPR
SCHEMBL18862045	0.82	GHSR (0.58)	GHSR
SCHEMBL18862054	0.82	GHSR (0.58)	GHSR
SCHEMBL18854328	0.81	GHSR (0.49)	GHSRGRPR
SCHEMBL18854276	0.80	GHSR (0.47)	GHSRGRPR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017083368-A1	TISSUE-SPECIFIC GENOME ENGINEERING USING CRISPR-CAS9	PFIZER INC. (US)	2017-05-18	—	—	WO	disclosed