Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.39 |
| ▸ | PLK1 | P53350 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23539559 | 0.78 | SMN1; SMN2 (0.43) | ALDH1A1HPGDHPGDSSMN1; SMN2LMNA | |
| SCHEMBL4711476 | 0.77 | ALDH1A1 (0.42) | ALDH1A1HPGDHPGDSSMN1; SMN2LMNA | |
| SCHEMBL20869079 | 0.75 | PDE3B (0.44) | ALDH1A1HPGDHPGDSSMN1; SMN2NUDT1 | |
| SCHEMBL28269734 | 0.73 | HPGD (0.42) | ALDH1A1HPGDHPGDSSMN1; SMN2LMNA | |
| SCHEMBL365712 | 0.72 | PLK1 (0.45) | ALDH1A1HPGDHPGDSLMNANUDT1 | |
| SCHEMBL26795976 | 0.71 | HPGDS (0.41) | ALDH1A1HPGDHPGDSSMN1; SMN2LMNA | |
| SCHEMBL26835463 | 0.71 | HPGDS (0.41) | ALDH1A1HPGDHPGDSSMN1; SMN2NUDT1 | |
| SCHEMBL14458098 | 0.70 | LMNA (0.43) | SMN1; SMN2LMNAMAPT | |
| SCHEMBL25338262 | 0.69 | HTT (0.48) | ALDH1A1LMNAMAPT | |
| SCHEMBL29626741 | 0.69 | CTSA (0.51) | ALDH1A1HPGDSSMN1; SMN2PLK1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3170810-B1 | PYRIDINE DERIVATIVES AND ANTI-MYCOBACTERIAL USE THEREOF | CISEN PHARMACEUTICAL CO LTD (CN) | 2018-09-19 | — | — | EP | disclosed |
| US-9878982-B2 | Pyridine derivatives and anti-mycobacterial use thereof | CISEN PHARMACEUTICAL CO., LTD. (CN) | 2018-01-30 | — | — | US | disclosed |
| EP-3170810-A1 | PYRIDINE DERIVATIVES AND ANTI-MYCOBACTERIAL USE THEREOF | Cisen Pharmaceutical Co. Ltd. (CN) | 2017-05-24 | — | — | EP | disclosed |