Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLO1 | Q04760 | 3/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18868644 | 0.70 | ALDH1A1 (0.45) | GLO1ALDH1A1PARP1SMN1; SMN2LMNA | |
| SCHEMBL27593827 | 0.69 | PARP1 (0.68) | EGLN1ALDH1A1PARP1HPGDSMN1; SMN2 | |
| SCHEMBL9701377 | 0.69 | PARP1 (0.58) | EGLN1ALDH1A1PARP1HPGDSMN1; SMN2 | |
| SCHEMBL10108717 | 0.68 | GLO1 (0.43) | GLO1EGLN1ALDH1A1PARP1HPGD | |
| SCHEMBL10108698 | 0.68 | GLO1 (0.43) | GLO1EGLN1ALDH1A1PARP1HPGD | |
| SCHEMBL29749881 | 0.68 | PARP1 (0.70) | EGLN1ALDH1A1PARP1HPGDSMN1; SMN2 | |
| SCHEMBL111826 | 0.68 | PARP1 (0.70) | EGLN1ALDH1A1PARP1HPGDSMN1; SMN2 | |
| SCHEMBL6983554 | 0.67 | EGLN1 (0.76) | EGLN1HPGDLMNAMEN1NPC1 | |
| Hydrochloric Acid SCHEMBL7320778 | 0.67 | PARP1 (0.68) | EGLN1ALDH1A1PARP1HPGDSMN1; SMN2 | |
| SCHEMBL16859274 | 0.67 | PARP1 (0.68) | EGLN1ALDH1A1PARP1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428504-B1 | Small molecule inhibitors of the pleckstrin homology domain and method for using same | UNIV TEXAS (US) | 2017-05-17 | — | — | EP | disclosed |