Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPL | P40238 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | ELAVL1 | Q15717 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | SUMO2 | P61956 | 1/20 | 0.35 |
| ▸ | SUMO1 | P63165 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1808666 | 0.85 | MPL (0.44) | MPLALDH1A1HIF1AGAAMAPT | |
| SCHEMBL3665117 | 0.81 | KDM4E (0.47) | MPLALDH1A1MAPTMEN1POLB | |
| SCHEMBL11499547 | 0.79 | LMNA (0.37) | ALDH1A1GAAMAPTMEN1POLB | |
| SCHEMBL28162127 | 0.78 | RAD1 (0.37) | MPLALDH1A1MAPTMEN1POLB | |
| SCHEMBL3098551 | 0.78 | ALDH1A1 (0.41) | ALDH1A1HIF1AMAPTMEN1POLB | |
| SCHEMBL8959215 | 0.77 | ALDH1A1 (0.42) | MPLALDH1A1HIF1AGAAMAPT | |
| SCHEMBL31120467 | 0.77 | RAPGEF4 (0.45) | ALDH1A1GAAMAPTMEN1POLB | |
| SCHEMBL2250284 | 0.76 | MPL (0.45) | MPLALDH1A1GAAMAPTMEN1 | |
| SCHEMBL26645 | 0.75 | MEP1B (0.49) | ALDH1A1GAAMAPTMEN1POLB | |
| SCHEMBL11327329 | 0.75 | MYC (0.41) | MPLALDH1A1HIF1AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2900656-B1 | SPIRO RING COMPOUNDS AS HEPATITIS C VIRUS (HCV) INHIBITORS | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-05-17 | — | — | EP | disclosed |