Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | XBP1 | P17861 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16254386 | 0.83 | ALDH1A1 (0.61) | ALDH1A1TP53TSHRCTSKKMT2A | |
| SCHEMBL18435448 | 0.83 | ALDH1A1 (0.61) | ALDH1A1TP53TSHRCTSKKMT2A | |
| SCHEMBL1705902 | 0.77 | CXCR2 (0.48) | ALDH1A1TP53TSHRCTSKKMT2A | |
| SCHEMBL10277769 | 0.75 | ALDH1A1 (0.44) | ALDH1A1TP53TSHRCTSKKMT2A | |
| SCHEMBL29954883 | 0.74 | CTSK (0.44) | ALDH1A1TP53TSHRCTSKKMT2A | |
| SCHEMBL29957138 | 0.74 | CTSK (0.44) | ALDH1A1TP53TSHRCTSKKMT2A | |
| SCHEMBL12980652 | 0.72 | C3AR1 (0.49) | ALDH1A1TP53TSHRCTSKKMT2A | |
| SCHEMBL4603000 | 0.71 | RAB9A (0.47) | ALDH1A1CTSK | |
| SCHEMBL13489680 | 0.71 | CTSK (0.43) | ALDH1A1TP53TSHRCTSKKMT2A | |
| SCHEMBL12980639 | 0.71 | C3AR1 (0.46) | ALDH1A1TP53TSHRCTSKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220009911-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2022-01-13 | — | — | US | disclosed |
| US-11040960-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2021-06-22 | — | — | US | disclosed |
| EP-3377059-B1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX INC (US) | 2020-10-21 | — | — | EP | disclosed |
| US-20200140418-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2020-05-07 | — | — | US | disclosed |
| US-10370363-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180170916-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2018-06-21 | — | — | US | disclosed |
| US-20180170916-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2018-06-21 | — | — | US | disclosed |
| US-9809581-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-9809581-B2 | Inhibitors of CXCR2 | CHEMOCENTRYX, INC. (US) | 2017-11-07 | — | — | US | disclosed |
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2017-05-25 | — | — | US | disclosed |
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CHEMOCENTRYX, INC. | 2017-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220009911-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885TP53 432/4885TSHR 3133/4885 |
| US-20170144996-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885TP53 432/4885TSHR 3133/4885 |
| US-20200140418-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885TP53 432/4885TSHR 3133/4885 |
| US-10370363-B2 | Inhibitors of CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885TP53 432/4885TSHR 3133/4885 |
| US-11040960-B2 | Inhibitors of CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885TP53 432/4885TSHR 3133/4885 |
| US-20180170916-A1 | INHIBITORS OF CXCR2 | CXCR2, CXCR3, CXCR1 | ALDH1A1 4057/4885TP53 432/4885TSHR 3134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.