Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | MAOB | P27338 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL189485 | 0.89 | RAB9A (0.50) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL189840 | 0.87 | RAB9A (0.59) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL253621 | 0.87 | MAOB (0.55) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL190218 | 0.87 | PARP10 (0.49) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL189690 | 0.87 | RAB9A (0.54) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL189407 | 0.86 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL189687 | 0.85 | CYP3A4 (0.52) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL190002 | 0.85 | MAOB (0.53) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL189765 | 0.85 | RAB9A (0.46) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT | |
| SCHEMBL189486 | 0.84 | MAOB (0.57) | SMN1; SMN2RAB9ANPC1L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9290464-B2 | Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2016-03-22 | — | — | US | claimed |
| EP-2401263-B1 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | SK BIOPHARMACEUTICALS CO LTD (KR) | 2016-02-17 | — | — | EP | claimed |
| US-20140350062-A1 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | SK BIOPHARMACEUTICALS CO LTD (KR) | 2014-11-27 | — | — | US | claimed |
| US-8841335-B2 | Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-09-23 | — | — | US | claimed |
| US-8828992-B2 | Substituted azole derivatives, pharmaceutical composition containing the derivatives, and method for treating Parkinson's disease using the same | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-09-09 | — | — | US | claimed |
| EP-2566475-A2 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | SK Biopharmaceuticals Co., Ltd. (KR) | 2013-03-13 | — | — | EP | claimed |
| US-20130046001-A1 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2013-02-21 | — | — | US | claimed |
| EP-2401263-A2 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | SK Biopharmaceuticals Co., Ltd. (KR) | 2012-01-04 | — | — | EP | claimed |
| US-20110301150-A1 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | SK BIOPHARMACEUTICALS CO., LTD. | 2011-12-08 | — | — | US | claimed |
| WO-2011139079-A2 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2011-11-10 | — | — | WO | claimed |
| WO-2010098600-A2 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | SK HOLDINGS CO., LTD. (KR) | 2010-09-02 | — | — | WO | claimed |
| US-9290464-B2 | Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2016-03-22 | — | — | US | disclosed |
| EP-2401263-B1 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | SK BIOPHARMACEUTICALS CO LTD (KR) | 2016-02-17 | — | — | EP | disclosed |
| US-20140350062-A1 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | SK BIOPHARMACEUTICALS CO LTD (KR) | 2014-11-27 | — | — | US | disclosed |
| US-8841335-B2 | Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2014-09-23 | — | — | US | disclosed |
| US-20130046001-A1 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2013-02-21 | — | — | US | disclosed |
| EP-2401263-A2 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | SK Biopharmaceuticals Co., Ltd. (KR) | 2012-01-04 | — | — | EP | disclosed |
| US-20110301150-A1 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | SK BIOPHARMACEUTICALS CO., LTD. | 2011-12-08 | — | — | US | disclosed |
| WO-2011139079-A2 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | SK BIOPHARMACEUTICALS CO., LTD. (KR) | 2011-11-10 | — | — | WO | disclosed |
| WO-2010098600-A2 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | SK HOLDINGS CO., LTD. (KR) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110301150-A1 | SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME | MAOB, MAOA, PARK7 | SMN1; SMN2 268/4885RAB9A 1245/4885NPC1 1852/4885 |
| US-20140350062-A1 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | BAX, NLN, CASP3 | SMN1; SMN2 15/4885RAB9A 2788/4885NPC1 134/4885 |
| US-20130046001-A1 | PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION | BAX, NLN, CASP3 | SMN1; SMN2 15/4885RAB9A 2788/4885NPC1 134/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.