SCHEMBL189840

SCHEMBL189840

NC(=O)OCc1cc(-c2ccc(OCc3ccccc3)cc2)no1

nearest known ligand 0.59

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 5/20 0.59
L3MBTL1 Q9Y468 5/20 0.59
NPC1 O15118 4/20 0.59
SMN1; SMN2 Q16637 4/20 0.59
TDP1 Q9NUW8 3/20 0.59
MAPT P10636 4/20 0.58
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
SMPD1 P17405 1/20 0.53
POLB P06746 2/20 0.51
MCL1 Q07820 2/20 0.50
PARP10 Q53GL7 1/20 0.48
XDH P47989 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL189525 0.95 RAB9A (0.60) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL190050 0.90 MAPT (0.52) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL189580 0.90 RAB9A (0.52) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL189528 0.90 SMN1; SMN2 (0.48) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL189410 0.89 RAB9A (0.51) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL189828 0.89 L3MBTL1 (0.61) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL189490 0.89 RAB9A (0.60) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL190288 0.89 PARP10 (0.56) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL190018 0.89 MAPT (0.50) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1
SCHEMBL14707191 0.88 RAB9A (0.61) RAB9AL3MBTL1NPC1SMN1; SMN2TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 66 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2917188-B1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SK BIOPHARMACEUTICALS CO LTD (KR) 2018-08-01 EP claimed
US-9724335-B2 Solid dispersions of insoluble drug and preparation method thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2017-08-08 US claimed
US-20170105973-A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SK BIOPHARMACEUTICALS CO., LTD. 2017-04-20 US claimed
US-9566268-B2 Solid dispersions of insoluble drug and preparation method thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2017-02-14 US claimed
US-20160346258-A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SK BIOPHARMACEUTICALS CO., LTD. 2016-12-01 US claimed
US-9439970-B2 Solid dispersions of insoluble drug and preparation method thereof SK BIOPHARMACEUTICALS CO., LTD. (KR) 2016-09-13 US claimed
US-9290464-B2 Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration SK BIOPHARMACEUTICALS CO., LTD. (KR) 2016-03-22 US claimed
EP-2401263-B1 SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME SK BIOPHARMACEUTICALS CO LTD (KR) 2016-02-17 EP claimed
US-20150283243-A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SK BIOPHARMACEUTICALS CO., LTD. a corporation 2015-10-08 US claimed
EP-2917188-A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SK Biopharmaceuticals Co., LTD (KR) 2015-09-16 EP claimed
US-20140350062-A1 PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION SK BIOPHARMACEUTICALS CO LTD (KR) 2014-11-27 US claimed
US-8841335-B2 Pharmaceutical composition for inhibiting apoptosis of neuron or neurodegeneration SK BIOPHARMACEUTICALS CO., LTD. (KR) 2014-09-23 US claimed
US-8828992-B2 Substituted azole derivatives, pharmaceutical composition containing the derivatives, and method for treating Parkinson's disease using the same SK BIOPHARMACEUTICALS CO., LTD. (KR) 2014-09-09 US claimed
WO-2014073889-A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SK BIOPHARMACEUTICALS CO., LTD. (KR) 2014-05-15 WO claimed
EP-2566475-A2 PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION SK Biopharmaceuticals Co., Ltd. (KR) 2013-03-13 EP claimed
US-20130046001-A1 PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION SK BIOPHARMACEUTICALS CO., LTD. (KR) 2013-02-21 US claimed
EP-2401263-A2 SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME SK Biopharmaceuticals Co., Ltd. (KR) 2012-01-04 EP claimed
US-20110301150-A1 SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME SK BIOPHARMACEUTICALS CO., LTD. 2011-12-08 US claimed
WO-2011139079-A2 PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION SK BIOPHARMACEUTICALS CO., LTD. (KR) 2011-11-10 WO claimed
WO-2010098600-A2 SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME SK HOLDINGS CO., LTD. (KR) 2010-09-02 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160346258-A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SI, CYP3A7, ABCG2 RAB9A 1475/4885L3MBTL1 4553/4885NPC1 162/4885
US-20110301150-A1 SUBSTITUTED AZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITION CONTAINING THE DERIVATIVES, AND METHOD FOR TREATING PARKINSON'S DISEASE USING THE SAME MAOB, MAOA, PARK7 RAB9A 1245/4885L3MBTL1 4729/4885NPC1 1852/4885
US-20140350062-A1 PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION BAX, NLN, CASP3 RAB9A 2788/4885L3MBTL1 2556/4885NPC1 134/4885
US-20170105973-A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SI, CYP3A7, ABCG2 RAB9A 1475/4885L3MBTL1 4553/4885NPC1 162/4885
US-20130046001-A1 PHARMACEUTICAL COMPOSITION FOR INHIBITING APOPTOSIS OF NEURON OR NEURODEGENERATION BAX, NLN, CASP3 RAB9A 2788/4885L3MBTL1 2556/4885NPC1 134/4885
US-20150283243-A1 SOLID DISPERSIONS OF INSOLUBLE DRUG AND PREPARATION METHOD THEREOF SI, ABCG2, CYP3A7 RAB9A 1774/4885L3MBTL1 3702/4885NPC1 306/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.