Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.34 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17857574 | 0.91 | MMP8 (0.42) | LMNAPOLBOPRK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL17841444 | 0.81 | GABRB1 (0.37) | LMNAOPRK1SMN1; SMN2GAAGABRB1 | |
| SCHEMBL17841446 | 0.81 | GABRB1 (0.37) | LMNAOPRK1SMN1; SMN2GAAGABRB1 | |
| SCHEMBL17841447 | 0.81 | GABRB1 (0.37) | LMNAOPRK1SMN1; SMN2GAAGABRB1 | |
| SCHEMBL23377637 | 0.80 | MAPT (0.40) | LMNAALDH1A1SMN1; SMN2GAAMMP8 | |
| SCHEMBL28553281 | 0.80 | MAPT (0.40) | LMNAALDH1A1SMN1; SMN2GAAMMP8 | |
| SCHEMBL29494599 | 0.79 | POLB (0.42) | LMNAPOLBALDH1A1SMN1; SMN2MMP8 | |
| SCHEMBL27406275 | 0.78 | ALDH1A1 (0.36) | POLBALDH1A1GAAMMP8 | |
| SCHEMBL18898548 | 0.73 | LMNA (0.45) | LMNAPOLBALDH1A1SMN1; SMN2GAA | |
| SCHEMBL17724358 | 0.73 | OPRK1 (0.37) | OPRK1NPC1RAB9ACHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9663516-B2 | Bicyclic-pyrimidinedione compounds | MyoKardia, Inc. (US) | 2017-05-30 | — | — | US | disclosed |