Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23377637 | 1.00 | MAPT (0.40) | MAPTSMN1; SMN2FBP1KMT2AMAPK1 | |
| SCHEMBL17857574 | 0.89 | MMP8 (0.42) | MAPTSMN1; SMN2KMT2ALMNAHTT | |
| SCHEMBL23373997 | 0.89 | MAPT (0.38) | MAPTSMN1; SMN2FBP1KMT2AMAPK1 | |
| SCHEMBL29494599 | 0.86 | POLB (0.42) | MAPTSMN1; SMN2FBP1KMT2ALMNA | |
| SCHEMBL23112568 | 0.82 | CTSL (0.37) | MAPK1HTTKDM4ECTSLALDH1A1 | |
| SCHEMBL23112570 | 0.82 | CTSL (0.37) | MAPK1HTTKDM4ECTSLALDH1A1 | |
| SCHEMBL23112571 | 0.82 | CTSL (0.37) | MAPK1HTTKDM4ECTSLALDH1A1 | |
| SCHEMBL27406275 | 0.81 | ALDH1A1 (0.36) | MAPTMAPK1KDM4EGAANPSR1 | |
| SCHEMBL18898421 | 0.80 | LMNA (0.37) | SMN1; SMN2LMNAGAAMMP8ALDH1A1 | |
| SCHEMBL29748442 | 0.76 | ALDH1A1 (0.42) | MAPTSMN1; SMN2FBP1KMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112469412-A | Substituted dihydropyrazolopyrazine carboxamide derivatives | 拜耳公司 | 2021-03-09 | — | — | CN | disclosed |