Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NMT1 | P30419 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18904027 | 0.80 | MAPT (0.50) | NPC1RAB9AMAPTSMN1; SMN2GAA | |
| SCHEMBL16503023 | 0.79 | SMN1; SMN2 (0.61) | MAPTSMN1; SMN2GAAL3MBTL1LMNA | |
| SCHEMBL18904188 | 0.75 | KMT2A (0.46) | POLBMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18903961 | 0.74 | NMT1 (0.52) | NPC1RAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL18904098 | 0.71 | L3MBTL1 (0.44) | NPC1RAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL854818 | 0.71 | L3MBTL1 (0.64) | NPC1RAB9APOLBMAPTSMN1; SMN2 | |
| SCHEMBL18903943 | 0.70 | HRH3 (0.43) | SMN1; SMN2L3MBTL1KDM4EALDH1A1LMNA | |
| SCHEMBL18903949 | 0.70 | HTT (0.38) | NPC1RAB9ASMN1; SMN2LMNAHTT | |
| SCHEMBL18903979 | 0.69 | SMN1; SMN2 (0.37) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18904149 | 0.69 | CYP11B2 (0.38) | MAPTSMN1; SMN2L3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2980076-B1 | Pyrazolyl derivatives | UNIV DUNDEE (GB) | 2017-05-31 | — | — | EP | disclosed |