Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 3/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SMYD2 | Q9NRG4 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15888456 | 0.81 | MAPK1 (0.37) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| SCHEMBL79874 | 0.81 | MAPK1 (0.37) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| Hydroxyamine SCHEMBL9901947 | 0.80 | ALDH1A1 (0.35) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| SCHEMBL704188 | 0.79 | MAPK1 (0.36) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| SCHEMBL31318429 | 0.77 | MAPK1 (0.34) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| SCHEMBL707572 | 0.77 | MAPK1 (0.34) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| SCHEMBL4835281 | 0.77 | MAPK1 (0.34) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| SCHEMBL19720997 | 0.77 | MAPK1 (0.34) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| SCHEMBL707090 | 0.77 | MAPK1 (0.34) | ALDH1A1ALOX15ESR1ESR2MAPK1 | |
| SCHEMBL26964680 | 0.77 | MAPK1 (0.34) | ALDH1A1ALOX15ESR1ESR2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10314922-B2 | Trimaleimide linkers and uses thereof | NEWBIO THERAPEUTICS, INC. (CN) | 2019-06-11 | — | — | US | disclosed |
| US-20180147295-A1 | Trimaleimide Linkers and Uses Thereof | NEWBIO THERAPEUTICS, INC. (CN) | 2018-05-31 | — | — | US | disclosed |
| US-9670266-B2 | Method and composition for crystallizing G protein-coupled receptors | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2017-06-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180147295-A1 | Trimaleimide Linkers and Uses Thereof | TXLNA, TRIM59, NAALAD2 | ALDH1A1 952/4885ALOX15 3205/4885ESR1 3993/4885 |
| US-10314922-B2 | Trimaleimide linkers and uses thereof | TXLNA, NAALAD2, TTL | ALDH1A1 1012/4885ALOX15 3539/4885ESR1 4233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.