Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYPLA2 | O95372 | 2/20 | 0.79 |
| ▸ | DAGLA | Q9Y4D2 | 18/20 | 0.61 |
| ▸ | ABHD6 | Q9BV23 | 16/20 | 0.61 |
| ▸ | LYPLA1 | O75608 | 1/20 | 0.57 |
| ▸ | ABHD11 | Q8NFV4 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30307838 | 0.72 | LYPLA2 (1.00) | LYPLA2DAGLAABHD6LYPLA1ABHD11 | |
| SCHEMBL22901703 | 0.64 | DAGLA (0.63) | LYPLA2DAGLALYPLA1 | |
| SCHEMBL1508235 | 0.62 | ALOX5 (0.50) | — | |
| SCHEMBL12834756 | 0.62 | SMN1; SMN2 (0.48) | — | |
| SCHEMBL17761098 | 0.61 | ALDH1A1 (0.54) | LYPLA2 | |
| SCHEMBL3355334 | 0.60 | HPGD (0.80) | — | |
| Fluorobenzene SCHEMBL28159220 | 0.60 | HPGD (0.55) | — | |
| SCHEMBL18867940 | 0.60 | HPGD (0.80) | — | |
| SCHEMBL17281605 | 0.60 | HPGD (0.47) | LYPLA2 | |
| SCHEMBL12833774 | 0.59 | RAB9A (0.73) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017096315-A1 | TRIAZOLE DAGL(α) INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2017-06-08 | — | — | WO | disclosed |