Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30088772 | 0.83 | ALDH1A1 (0.43) | TRPM8FAAHCES1LTA4H | |
| SCHEMBL18969621 | 0.81 | EDNRA (0.37) | TRPM8FAAH | |
| SCHEMBL11967752 | 0.79 | ELANE (0.38) | TRPM8FAAHNPSR1 | |
| SCHEMBL14084500 | 0.75 | POLB (0.35) | TRPM8 | |
| SCHEMBL21938419 | 0.75 | MLYCD (0.34) | TRPM8FAAHKMT2ANPSR1 | |
| SCHEMBL4154644 | 0.71 | PAX8 (0.35) | TRPM8FAAH | |
| SCHEMBL4764157 | 0.71 | — | — | |
| SCHEMBL27744873 | 0.70 | TRPM8 (0.39) | TRPM8FAAHCES1KMT2ANPSR1 | |
| SCHEMBL4722845 | 0.69 | — | — | |
| SCHEMBL4721756 | 0.69 | GBA1 (0.35) | TRPM8KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017100558-A1 | IMPROVED APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2017-06-15 | — | — | WO | disclosed |
| US-20170166577-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2017-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166577-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | TRPM8 589/4885FAAH 473/4885CES1 4411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.