Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18964100 | 0.70 | TRPM8 (0.37) | TRPM8FAAHCES1KMT2ANPSR1 | |
| SCHEMBL28941701 | 0.69 | PKM (0.47) | TRPM8SMN1; SMN2L3MBTL1ALDH1A1PKM | |
| SCHEMBL2422303 | 0.68 | FAAH (0.43) | NUDT1PIK3CAL3MBTL1ALDH1A1PKM | |
| SCHEMBL11776990 | 0.68 | CTDSP1 (0.48) | L3MBTL1ALDH1A1HSD17B10KDM4ECASP1 | |
| SCHEMBL30753499 | 0.67 | FAAH (0.42) | ADORA2AADORA2BNUDT1PIK3CAL3MBTL1 | |
| SCHEMBL11264225 | 0.66 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1LMNAKMT2ANPSR1 | |
| Benzene SCHEMBL30353855 | 0.66 | CES1 (0.43) | ADORA2AADORA2BNUDT1L3MBTL1ALDH1A1 | |
| SCHEMBL3229623 | 0.66 | CES1 (0.41) | ALDH1A1PKMFAAHCES1CYP1A2 | |
| SCHEMBL30088772 | 0.66 | ALDH1A1 (0.43) | TRPM8L3MBTL1ALDH1A1FAAHCES1 | |
| SCHEMBL23484862 | 0.66 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101420950-B | Treatment of duchenne muscular dystrophy | SUMMIT CORP PLC | 2012-04-18 | — | — | CN | disclosed |
| CN-101678107-A | Pharmaceutical composition for treating Duchenne muscular dystrophy | SUMMIT CORP PLC | 2010-03-24 | — | — | CN | disclosed |
| CN-101420950-A | Treatment of Duchenne muscular dystrophy | SUMMIT CORP PLC (GB) | 2009-04-29 | — | — | CN | disclosed |