Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 5/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.37 |
| ▸ | F11 | P03951 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18976007 | 1.00 | NAMPT (0.41) | NAMPTPTPN2PTPN1PTPN6NPC1 | |
| SCHEMBL20580941 | 0.81 | JAK1 (0.41) | PTPN2PTPN1NPC1RAB9AF11 | |
| SCHEMBL18976466 | 0.77 | HRAS (0.41) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL18976140 | 0.75 | HRH4 (0.38) | NPC1RAB9AALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL22928845 | 0.75 | RAB9A (0.63) | NAMPTNPC1RAB9APARP1ALDH1A1 | |
| SCHEMBL15155596 | 0.75 | PTPN2 (0.61) | PTPN2PTPN1PTPN6NPC1RAB9A | |
| SCHEMBL18976321 | 0.74 | ALDH1A1 (0.46) | PTPN2PTPN1NPC1RAB9AALDH1A1 | |
| SCHEMBL16366856 | 0.71 | PTPN2 (0.56) | PTPN2PTPN1PTPN6NPC1RAB9A | |
| SCHEMBL26134509 | 0.71 | ABL1 (0.52) | NAMPTPTPN2PTPN1PTPN6NPC1 | |
| SCHEMBL4711280 | 0.70 | CTSK (0.45) | NAMPTHPGDCA1CA2BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | KING'S COLLEGE LONDON (GB) | 2020-05-05 | — | — | US | disclosed |
| WO-2017098257-A1 | PBD ANTIBACTERIAL AGENTS | KING'S COLLEGE LONDON (GB) | 2017-06-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10640507-B2 | PBD antibacterial agents | OPRD1, XDH, SBDS | NAMPT 4610/4885PTPN2 1714/4885PTPN1 2014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.