SCHEMBL18979181

SCHEMBL18979181

Cn1c(-c2ccc(C(F)(F)F)cc2)cnc1-c1ccc(C(F)(F)F)cc1F

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 1/20 0.50
TP53 P04637 2/20 0.47
GAA P10253 2/20 0.47
MAPT P10636 2/20 0.47
POLB P06746 1/20 0.47
FEN1 P39748 13/20 0.45
ALOX5AP P20292 12/20 0.45
APP P05067 1/20 0.43
DYRK1A Q13627 2/20 0.40
DYRK2 Q92630 2/20 0.40
DYRK3 O43781 1/20 0.40
CCNA2 P20248 1/20 0.40
CDK2 P24941 1/20 0.40
DYRK1B Q9Y463 1/20 0.40
MPL P40238 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19219733 0.95 MAPT (0.51) HSD11B1TP53GAAMAPTPOLB
SCHEMBL30843064 0.81 MAPT (0.50) TP53GAAMAPTPOLBFEN1
SCHEMBL30843112 0.81 TP53 (0.46) TP53GAAMAPTPOLBFEN1
SCHEMBL18979134 0.80 TP53 (0.45) HSD11B1TP53GAAMAPTPOLB
SCHEMBL18751256 0.79 TP53 (0.44) TP53GAAMAPTPOLBFEN1
SCHEMBL19219730 0.76 MAPT (0.48) TP53GAAMAPTPOLBFEN1
SCHEMBL19219734 0.75 TP53 (0.47) TP53GAAMAPTPOLBFEN1
SCHEMBL30843065 0.74 ALOX5AP (0.47) TP53GAAMAPTPOLBFEN1
SCHEMBL18979159 0.73 MAPT (0.43) HSD11B1TP53GAAMAPTPOLB
SCHEMBL18979063 0.72 APP (0.42) HSD11B1FEN1ALOX5APAPPMPL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220000112-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2022-01-06 US disclosed
US-20220000112-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2022-01-06 US disclosed
EP-3766871-A1 DIARYLIMIDAZOLE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2021-01-20 EP disclosed
EP-3766871-A1 DIARYLIMIDAZOLE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2021-01-20 EP disclosed
EP-3181552-B1 DIARYL IMIDAZOLE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO (JP) 2020-10-21 EP disclosed
EP-3181552-B1 DIARYL IMIDAZOLE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO (JP) 2020-10-21 EP disclosed
CN-106573894-B Diaryl imidazole compound and pest control agent 日本曹达株式会社 2020-10-13 CN disclosed
US-20200187501-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2020-06-18 US disclosed
US-20200187501-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2020-06-18 US disclosed
US-20180289006-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2018-10-11 US disclosed
US-10021880-B2 Diarylimidazole compound and harmful organism control agent NIPPON SODA CO., LTD. (JP) 2018-07-17 US disclosed
US-10021880-B2 Diarylimidazole compound and harmful organism control agent NIPPON SODA CO., LTD. (JP) 2018-07-17 US disclosed
US-20170223958-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2017-08-10 US disclosed
US-20170223958-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2017-08-10 US disclosed
EP-3181552-A1 DIARYL IMIDAZOLE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2017-06-21 EP disclosed
EP-3181552-A1 DIARYL IMIDAZOLE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2017-06-21 EP disclosed
CN-106573894-A Diaryl imidazole compound and pest control agent 日本曹达株式会社 2017-04-19 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10021880-B2 Diarylimidazole compound and harmful organism control agent NOX1, L3MBTL1, MRM1 HSD11B1 769/4885TP53 3609/4885GAA 3504/4885
US-20200187501-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NOX1, L3MBTL1, MRM1 HSD11B1 769/4885TP53 3609/4885GAA 3504/4885
US-20180289006-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NOX1, L3MBTL1, MRM1 HSD11B1 769/4885TP53 3609/4885GAA 3504/4885
US-20220000112-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NOX1, L3MBTL1, MRM1 HSD11B1 769/4885TP53 3609/4885GAA 3504/4885
US-20170223958-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NOX1, L3MBTL1, MRM1 HSD11B1 769/4885TP53 3609/4885GAA 3504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.