SCHEMBL19219733

SCHEMBL19219733

Cc1ccc(-c2cnc(-c3ccc(C(F)(F)F)cc3F)n2C)cc1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.51
TP53 P04637 3/20 0.51
GAA P10253 3/20 0.51
POLB P06746 1/20 0.51
HSD11B1 P28845 1/20 0.48
FEN1 P39748 12/20 0.43
ALOX5AP P20292 11/20 0.43
NPC1 O15118 1/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C19 P33261 1/20 0.39
RAB9A P51151 1/20 0.39
APP P05067 1/20 0.39
CYP11B1 P15538 1/20 0.38
CYP11B2 P19099 1/20 0.38
NPBWR1 P48145 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18979181 0.95 HSD11B1 (0.50) MAPTTP53GAAPOLBHSD11B1
SCHEMBL19219730 0.81 MAPT (0.48) MAPTTP53GAAPOLBFEN1
SCHEMBL19219734 0.80 TP53 (0.47) MAPTTP53GAAPOLBFEN1
SCHEMBL30843064 0.77 MAPT (0.50) MAPTTP53GAAPOLBFEN1
SCHEMBL30843112 0.77 TP53 (0.46) MAPTTP53GAAPOLBFEN1
SCHEMBL18979134 0.76 TP53 (0.45) MAPTTP53GAAPOLBHSD11B1
SCHEMBL19219732 0.75 HSD11B1 (0.41) MAPTTP53GAAPOLBHSD11B1
SCHEMBL18751256 0.75 TP53 (0.44) MAPTTP53GAAPOLBFEN1
SCHEMBL15426486 0.71 HSD11B1 (0.47) POLBHSD11B1FEN1ALOX5APCYP1A2
SCHEMBL15426497 0.70 HSD11B1 (0.49) HSD11B1NPBWR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220000112-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2022-01-06 US disclosed
US-10021880-B2 Diarylimidazole compound and harmful organism control agent NIPPON SODA CO., LTD. (JP) 2018-07-17 US disclosed
US-20170223958-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2017-08-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10021880-B2 Diarylimidazole compound and harmful organism control agent NOX1, L3MBTL1, MRM1 MAPT 4473/4885TP53 3609/4885GAA 3504/4885
US-20220000112-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NOX1, L3MBTL1, MRM1 MAPT 4473/4885TP53 3609/4885GAA 3504/4885
US-20170223958-A1 DIARYLIMIDAZOLE COMPOUND AND HARMFUL ORGANISM CONTROL AGENT NOX1, L3MBTL1, MRM1 MAPT 4473/4885TP53 3609/4885GAA 3504/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.