Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA9 | Q16790 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | NAMPT | P43490 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.43 |
| ▸ | TP53 | P04637 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19003274 | 0.86 | MMP1 (0.58) | CA12CA1CA2CA9MAPT | |
| SCHEMBL19003307 | 0.83 | EGFR (0.60) | NAMPTMAPTLMNAKMT2AMEN1 | |
| SCHEMBL19003250 | 0.82 | MAPT (0.51) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL19003310 | 0.81 | ALDH1A1 (0.59) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL18985197 | 0.81 | MEN1 (0.55) | NAMPTMAPTLMNAKMT2AMEN1 | |
| SCHEMBL19003313 | 0.80 | SAE1 (0.46) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL19003248 | 0.80 | LMNA (0.56) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL19003264 | 0.79 | NR4A1 (0.56) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL19003283 | 0.78 | RAB9A (0.52) | MAPTLMNAKMT2AMEN1NPC1 | |
| SCHEMBL19003257 | 0.77 | KDM4E (0.49) | MAPTLMNAKMT2AMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | claimed |
| WO-2017102014-A1 | PROPENAMIDE THIOPHENE DERIVATIVES AS FLAVIVIRUS INHIBITORS AND THEIR USE | UNIVERSITE D'AIX-MARSEILLE (FR) | 2017-06-22 | — | — | WO | disclosed |