Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 3/20 | 0.37 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365208 | 0.94 | TDP1 (0.48) | MAPK1TDP1CYP3A4TRPA1MAOA | |
| SCHEMBL894324 | 0.94 | TDP1 (0.48) | MAPK1TDP1CYP3A4TRPA1MAOA | |
| SCHEMBL894657 | 0.90 | TDP1 (0.47) | MAPK1TDP1CYP3A4TRPA1ALDH1A1 | |
| SCHEMBL11206075 | 0.85 | MAPK1 (0.41) | MAPK1TDP1CYP3A4TRPA1ALDH1A1 | |
| SCHEMBL29849714 | 0.85 | AGXT (0.40) | MAPK1TDP1CYP3A4TRPA1ALDH1A1 | |
| SCHEMBL29849567 | 0.85 | AGXT (0.40) | MAPK1TDP1CYP3A4TRPA1ALDH1A1 | |
| SCHEMBL18936487 | 0.83 | CYP3A4 (0.44) | MAPK1TDP1CYP3A4TRPA1ALDH1A1 | |
| Biphenyl SCHEMBL28576528 | 0.82 | CYP3A4 (0.54) | MAPK1TDP1CYP3A4TRPA1ALDH1A1 | |
| SCHEMBL27873 | 0.82 | TDP1 (0.54) | MAPK1TDP1CYP3A4TRPA1ALDH1A1 | |
| SCHEMBL10615043 | 0.82 | TDP1 (0.54) | MAPK1TDP1CYP3A4TRPA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2023-08-01 | — | — | US | disclosed |
| US-20210009621-A1 | AMINOCOUMARIN COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-01-14 | — | — | US | disclosed |
| US-20210009621-A1 | AMINOCOUMARIN COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2021-01-14 | — | — | US | disclosed |
| WO-2019178119-A1 | AMINOCOUMARIN COMPOUNDS AND METHODS OF THEIR USE | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2019-09-19 | — | — | WO | disclosed |
| EP-2496549-B1 | NEW, NON-CRYSTALLISING METHACRYLATE, ITS MANUFACTURE AND APPLICATION | BAYER IP GMBH (DE) | 2014-10-08 | — | — | EP | disclosed |
| US-8404690-B2 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2013-03-26 | — | — | US | disclosed |
| EP-2496549-A2 | NOVEL NON-CRYSTALLIZING METHACRYLATES, PRODUCTION AND USE THEREOF | Bayer MaterialScience AG (DE) | 2012-09-12 | — | — | EP | disclosed |
| US-20120219885-A1 | NOVEL NON-CRYSTALLIZING METHACRYLATES, PRODUCTION AND USE THEREOF | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2012-08-30 | — | — | US | disclosed |
| WO-2011054818-A2 | NOVEL NON-CRYSTALLIZING METHACRYLATES, PRODUCTION AND USE THEREOF | BAYER MATERIALSCIENCE AG (DE) | 2011-05-12 | — | — | WO | disclosed |
| EP-1592389-B1 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | SERONO LAB (CH) | 2009-04-22 | — | — | EP | disclosed |
| US-20080171783-A1 | COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE | MIGENIX INC. (CA) | 2008-07-17 | — | — | US | disclosed |
| WO-2008080223-A1 | COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE | MIGENIX INC. (CA) | 2008-07-10 | — | — | WO | disclosed |
| EP-1910279-A2 | NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF | MIGENIX INC. (CA) | 2008-04-16 | — | — | EP | disclosed |
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | MERCK SERONO SA (CH) | 2007-06-21 | — | — | US | disclosed |
| US-20070021434-A1 | NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF | MIGENIX INC. (CA) | 2007-01-25 | — | — | US | disclosed |
| WO-2007002639-A2 | NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF | MIGENIX INC. (CA) | 2007-01-04 | — | — | WO | disclosed |
| EP-1592389-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | Applied Research Systems ARS Holding N.V. (AN) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004071390-A2 | PIPERAZINE-2-CARBOXAMIDE DERIVATIVES | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021434-A1 | NON-NUCLEOSIDE ANTI-HEPACIVIRUS AGENTS AND USES THEREOF | HAVCR2, ADAR, NSUN2 | MAPK1 3620/4885TDP1 2950/4885CYP3A4 2552/4885 |
| US-20120219885-A1 | NOVEL NON-CRYSTALLIZING METHACRYLATES, PRODUCTION AND USE THEREOF | MEP1A, MMAB, RHOA | MAPK1 2487/4885TDP1 2648/4885CYP3A4 2674/4885 |
| US-20210009621-A1 | AMINOCOUMARIN COMPOUNDS AND METHODS OF THEIR USE | AAAS, PROC, AADAC | MAPK1 4577/4885TDP1 2795/4885CYP3A4 122/4885 |
| US-20080171783-A1 | COMPOSITIONS AND METHODS FOR TREATING HYPERPROLIFERATIVE DISEASE | POLQ, POLI, POLH | MAPK1 3326/4885TDP1 82/4885CYP3A4 4761/4885 |
| US-20070142391-A1 | Piperazine-2-carboxamide derivatives | P2RX5, P2RX2, NPY5R | MAPK1 3742/4885TDP1 3019/4885CYP3A4 1325/4885 |
| US-11713335-B2 | Aminocoumarin compounds and methods of their use | AAAS, PROC, AADAC | MAPK1 4577/4885TDP1 2795/4885CYP3A4 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.