Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 2/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.38 |
| ▸ | PER2 | O15055 | 1/20 | 0.38 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.38 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1662507 | 0.79 | L3MBTL1 (0.41) | CA2L3MBTL1MAPTGFERNPSR1 | |
| SCHEMBL12994623 | 0.78 | MAPT (0.48) | CA2CA1CA9L3MBTL1MAPT | |
| SCHEMBL16914864 | 0.77 | PER2 (0.39) | CA2CA1CYP2A6PLCG1PER2 | |
| SCHEMBL1334344 | 0.76 | ENPP2 (0.50) | CA2CA1CA9L3MBTL1MAPT | |
| SCHEMBL21314563 | 0.76 | ACLY (0.30) | — | |
| SCHEMBL3030207 | 0.76 | TDP1 (0.48) | CA2CA1CA9L3MBTL1MAPT | |
| SCHEMBL5479553 | 0.76 | APLNR (0.39) | CA2CA1CA9TDP1LMNA | |
| SCHEMBL2513199 | 0.75 | NR3C2 (0.44) | CA2CA9NPSR1SMN1; SMN2ALDH1A1 | |
| SCHEMBL18346856 | 0.74 | PER2 (0.47) | PLCG1PER2CRY1CRY2L3MBTL1 | |
| SCHEMBL2329697 | 0.73 | SMN1; SMN2 (0.37) | CA2CA1CA9PER2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420695-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-04-16 | — | — | US | disclosed |
| US-8420695-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-04-16 | — | — | US | disclosed |
| US-8420695-B2 | Inhibitors of janus kinases | MERCK SHARP & DOHME CORP. (US) | 2013-04-16 | — | — | US | disclosed |
| US-20110112081-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2011-05-12 | — | — | US | disclosed |
| US-20110112081-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2011-05-12 | — | — | US | disclosed |
| US-20110112081-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112081-A1 | INHIBITORS OF JANUS KINASES | JAK2, JAK3, JAK1 | CA2 4067/4885CA1 4779/4885CA9 4208/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.