Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1916178 | 0.79 | ALDH1A1 (0.52) | TDP1CYP3A4ALDH1A1MAPK1TP53 | |
| SCHEMBL12994623 | 0.78 | MAPT (0.48) | TDP1ALDH1A1MAPK1TSHRL3MBTL1 | |
| SCHEMBL2329697 | 0.77 | SMN1; SMN2 (0.37) | ALDH1A1LMNACA1CA2CA12 | |
| SCHEMBL20734785 | 0.76 | CYP3A4 (0.42) | TDP1CYP3A4ALDH1A1MAPK1TP53 | |
| SCHEMBL1899321 | 0.76 | CA2 (0.40) | TDP1ALDH1A1TSHRL3MBTL1GFER | |
| SCHEMBL1334344 | 0.76 | ENPP2 (0.50) | CYP3A4ALDH1A1TP53ALOX15L3MBTL1 | |
| SCHEMBL2993431 | 0.76 | ALDH1A1 (0.43) | TDP1CYP3A4ALDH1A1MAPK1TP53 | |
| SCHEMBL2513199 | 0.75 | NR3C2 (0.44) | ALDH1A1ALOX15HTR6CA2CA12 | |
| SCHEMBL16423298 | 0.74 | LMNA (0.45) | TDP1CYP3A4ALDH1A1TSHRL3MBTL1 | |
| SCHEMBL7850305 | 0.73 | MMP2 (0.39) | TDP1CYP3A4ALDH1A1MAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609713-B2 | Pyrrole derivatives and their methods of use | ABBVIE INC. (US) | 2013-12-17 | — | — | US | disclosed |
| US-20100216748-A1 | Pyrrole Derivatives and Their Methods of Use | ABBOTT LABORATORIES (US) | 2010-08-26 | — | — | US | disclosed |
| US-7741364-B2 | Neuronal nicotinic acetylcholine receptor modulators; such as ethyl 1-[4-(aminosulfonyl)phenyl]-5-(4-bromophenyl)-2-methyl-1H-pyrrole-3-carboxylate | ABBOTT LABORATORIES (US) | 2010-06-22 | — | — | US | disclosed |
| EP-2041085-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | Abbott Laboratories (US) | 2009-04-01 | — | — | EP | disclosed |
| US-20080064695-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | ABBVIE INC. | 2008-03-13 | — | — | US | disclosed |
| WO-2008005303-A2 | THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-10 | — | — | WO | disclosed |
| WO-2008002974-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | ABBOTT LABORATORIES (US) | 2008-01-03 | — | — | WO | disclosed |
| US-20080004253-A1 | Thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | US | disclosed |
| US-20080004253-A1 | Thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-03 | — | — | US | disclosed |
| US-5420292-A | Biphenyl-tetrazole intermediate compounds | ZENECA LIMITED (GB) | 1995-05-30 | — | — | US | disclosed |
| US-5294716-A | Chemical process for making angiotesin II antagonist compounds | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-03-15 | — | — | US | disclosed |
| EP-0031698-B1 | XANTHENE DYES AND PHOTOGRAPHIC PRODUCTS AND PROCESSES UTILISING THEM | POLAROID CORPORATION (US) | 1984-06-20 | — | — | EP | disclosed |
| US-4429142-A | PHOTOGRAPHIC LIGHT-SCREENING DYES | POLAROID CORPORATION (US) | 1984-01-31 | — | — | US | disclosed |
| US-4345017-A | ANTIHALATION AGENTS, FILTERS, ANTISOILANTS TO ADJUST COLOR BALANCE OF LIGHT SENSITIVE ELEMENTS; COLOR FILMS; SELF-DEVELOPMENT/PHOTO/ | POLAROID CORPORATION (US) | 1982-08-17 | — | — | US | disclosed |
| US-4307017-A | LIGHT SCREENING DYES IN PHOTOGRAPHIC PRODUCTS | POLAROID CORPORATION (US) | 1981-12-22 | — | — | US | disclosed |
| US-4304834-A | LIGHT-SCREENING DYES; COLOR FILMS; SILVER HALIDE EMULSIONS | POLAROID CORPORATION (US) | 1981-12-08 | — | — | US | disclosed |
| EP-0031698-A1 | Xanthene dyes and photographic products and processes utilising them | POLAROID CORPORATION (US) | 1981-07-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080064695-A1 | PYRROLE DERIVATIVES AND THEIR METHODS OF USE | PYCR1, PPOX, DHPS | TDP1 494/4885CYP3A4 458/4885ALDH1A1 745/4885 |
| US-20080004253-A1 | Thiazolopyrimidine modulators of TRPV1 | TRPV1, TRPA1, TRPV2 | TDP1 2870/4885CYP3A4 2297/4885ALDH1A1 2286/4885 |
| US-20100216748-A1 | Pyrrole Derivatives and Their Methods of Use | PYCR1, PPOX, DHPS | TDP1 494/4885CYP3A4 458/4885ALDH1A1 745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.