Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | CASP7 | P55210 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20093628 | 0.84 | HSD17B10 (0.38) | SIRT1SMN1; SMN2HPGDCASP7HSD17B10 | |
| SCHEMBL4135611 | 0.81 | ALDH1A1 (0.43) | NOS3NOS2HPGDHSD17B10POLB | |
| SCHEMBL10157973 | 0.78 | SIRT1 (0.37) | SIRT1SMN1; SMN2HPGDCASP7HSD17B10 | |
| SCHEMBL19932128 | 0.77 | NOS3 (0.38) | SIRT1NOS3NOS2SMN1; SMN2LMNA | |
| SCHEMBL17232508 | 0.77 | NOS3 (0.38) | NOS3NOS2LMNACYP3A4MAPT | |
| SCHEMBL5195607 | 0.77 | TRPA1 (0.41) | NOS3NOS2ESR1ARESR2 | |
| SCHEMBL19116110 | 0.77 | GAA (0.36) | SIRT1SMN1; SMN2HPGDCASP7HSD17B10 | |
| SCHEMBL10157945 | 0.76 | SIRT1 (0.36) | SIRT1HPGDMEN1KMT2APTGS1 | |
| SCHEMBL17066477 | 0.76 | CYP3A4 (0.41) | NOS3NOS2ESR1CYP3A4AR | |
| SCHEMBL13057531 | 0.76 | GABRA1 (0.50) | NOS3NOS2POLBPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906539-B1 | INHIBITORS OF VIRAL REPLICATION, THEIR PROCESS OF PREPARATION AND THEIR THERAPEUTICAL USES | HIVIH (FR) | 2017-06-21 | — | — | EP | disclosed |