Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | AHCY | P23526 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | TYMP | P19971 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALB | P02768 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24600792 | 0.84 | LMNA (0.47) | PDE4DP2RX7ALDH1A1LMNATP53 | |
| SCHEMBL22820040 | 0.79 | CYP2C19 (0.42) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL24021920 | 0.79 | ALDH1A1 (0.47) | PDE4APDE4BPDE4CPDE4DHIF1A | |
| SCHEMBL2035453 | 0.79 | ALDH1A1 (0.60) | HIF1AALDH1A1MAPK1LMNAALB | |
| SCHEMBL24600957 | 0.79 | ALDH1A1 (0.60) | HIF1AALDH1A1MAPK1LMNAALB | |
| SCHEMBL2035452 | 0.79 | ALDH1A1 (0.60) | HIF1AALDH1A1MAPK1LMNAALB | |
| SCHEMBL6838208 | 0.78 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DADORA2A | |
| SCHEMBL12826793 | 0.77 | PDE4D (0.55) | PDE4DADORA2ALMNATP53ADORA3 | |
| SCHEMBL24021895 | 0.76 | ALDH1A1 (0.45) | PDE4APDE4BPDE4CPDE4DP2RX7 | |
| SCHEMBL15713382 | 0.74 | DNPH1 (0.47) | PDE4DALDH1A1MAPK1LMNAALB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137202-B1 | PROCESS FOR THE SYNTHESIS OF IB-MECA | CAN-FITE BIOPHARMA LTD (IL) | 2017-06-21 | — | — | EP | disclosed |